Synthesis of Ferrocenyl-1-(4-pyridylmethyl)- and Ferrocenyl-1-[2-hydroxy-1,2-bis(4-pyridyl)ethyl]pyrazoles

Eduardo A. Vázquez López; Elena I. Klimova; Tatiana Klimova; Cecilio Alvarez Toledano; Lena Ruíz Ramírez; Ruben Alfredo Toscano; Marcos Martínez García

doi:10.1055/s-2004-831204

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Synthesis of Ferrocenyl-1-(4-pyridylmethyl)- and Ferrocenyl-1-[2-hydroxy-1,2-bis(4-pyridyl)ethyl]pyrazoles

Eduardo A. Vázquez López^a, Elena I. Klimova*^a, Tatiana Klimova^a, Cecilio Alvarez Toledano^b, Lena Ruíz Ramírez^a, Ruben Alfredo Toscano^b, Marcos Martínez García^b
^a Facultad de Química, Universidad Nacional Autónoma de México, Cd. Universitaria, Coyoacán, C.P. 04510, México D.F., México
^b Instituto de Química, Universidad Nacional Autónoma de México, Cd. Universitaria, Coyoacán, C.P. 04510, México D.F., México
Fax: +52(5)556225371; e-Mail: klimova@servidor.unam.mx;

Abstract

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Abstract

Pyridine-4-carbaldehyde reacts with ferrocenyl-4,5-dihydropyrazoles to yield ferrocenyl-1-(4-pyridylmethyl)pyrazoles and ferrocenyl-1-[2-hydroxy-1,2-bis(4-pyridyl)ethyl]pyrazoles. The structures of the compounds obtained were established based on spectroscopic (IR, mass, ¹H and ¹³C NMR) data. X-ray diffraction data for 4-[3-(p-bromophenyl)-5-ferrocenyl-1-(4-pyridyl)-methylpyrazole corroborate its structure.

Key words

α,β-unsaturated ketones - ferrocenylpyrazolines - ferrocenyl-1-(4-pyridylmethyl)pyrazoles - ferrocenyl-1-[2-hydroxy-1,2-bis(4-pyridyl)ethyl]pyrazoles

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