Improved Synthesis of 1,3-Propanediol Derivatives Having a Diethoxyphosphoryldifluoroethyl Functional Group at the 2-Position: Application to Chemoenzymatic Synthesis of Novel Acyclic Nucleotide Analogues of Adenosine Bisphosphates

Abstract

An alternative synthesis of 1,3-propanediol 1 having a diethoxyphosphoryldifluoroethyl group was examined. The method readily provided a multi-gram quantity of 1. The propanediol 1 was chemo-enzymatically transformed to acyclic nucleotide analogues for adenosine bisphosphates.

Key words

1,3-propanediols - fluorine - transesterifications - chiral pool - nucleotide analogues

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