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Synlett 2004(15): 2821-2823
DOI: 10.1055/s-2004-835624
DOI: 10.1055/s-2004-835624
LETTER
© Georg Thieme Verlag Stuttgart · New York
Solid-Phase Synthesis of a Double 4-Pyridinyl Terminated Leu-Ala-Leu Tripeptide and Macrocyclization by Palladium(II) Coordination
Further Information
Publication History
Received
25 August 2004
Publication Date:
22 October 2004 (online)


Abstract
A Leu-Ala-Leu tripeptide, which bears pyridinyl units at the N- as well as C-terminus, is prepared by combination of solid- and solution-phase synthesis. With the Pd(en)2+ fragment it forms a mixture of 1:1 and 2:2 complexes, with the mononuclear complex probably being the dominating species.
Key words
solid-phase - coupling - pyridines - peptides - macrocycles