Abstract
HCl-catalyzed Mannich reaction of cyclic ketone, aromatic aldehyde, and aromatic amine proceeded smoothly in water in the presence of SDS to afford the corresponding β-amino ketone with high anti selectivity.
Key words
Mannich reactions - Brønsted acid - water - amines - surfactant
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11 Although Brønsted acid-catalyzed Mannich reactions have been reported,
[9 10
12 We have not observed the diaminoalkylation product.
13 Other acyclic ketones such as 2-butanone and propiophenone did not give the Mannich adduct.
