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DOI: 10.1055/s-2004-837300
Fast and Convenient Synthesis of α-N-Protected Amino Acid Hydrazides
Publication History
Received
10 September 2004
Publication Date:
22 December 2004 (online)


Abstract
A fast, simple and convenient synthesis of α-N-protected amino acid hydrazides is reported. The procedure involves the reaction between hydrazine monohydrate and the mixed anhydride obtained from an α-N-protected amino acid and ethyl chloroformate. When methylhydrazine was used, the reaction showed a good selectivity, yielding a mixture of 1-acyl-1-methylhydrazine and 1-acyl-2-methylhydrazine in a ratio 87:13. In contrast, when the reaction was carried out with phenylhydrazine, only 1-acyl-2-phenylhydrazine was obtained. No significant difference in reactivity was observed with the different amino acids and N-protection introduced.
Key words
amino acids - hydrazides - regioselectivity - anhydrides - protecting groups