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DOI: 10.1055/s-2005-837753
© Georg Thieme Verlag KG Stuttgart · New York
Antimicrobial Activity of Sesquiterpenes from the Essential Oil of Juniperus thurifera Wood
Publication History
Received: March 26, 2004
Accepted: July 24, 2004
Publication Date:
27 January 2005 (online)
![](https://www.thieme-connect.de/media/plantamedica/200501/lookinside/thumbnails/10.1055-s-2005-837753-1.jpg)
Abstract
Chemical analysis of the essential oil of Juniperus thurifera wood led to the identification of fifty-eight sesquiterpene compounds, of which twenty-eight have been isolated, two of them being new natural cedrane derivatives (1 and 2). Their structures were established on the basis of 1D NMR and 2D NMR spectra. The antimicrobial activities of different pure compounds of this oil were tested against nine microorganisms (Gram-positive and Gram-negative bacteria, and yeasts). Seven of the tested compounds exhibited a relevant activity, with the known α- and β-cedrenes and sesquithuriferol showing minimum inhibitory concentrations of 3.06 μg/mL against Bacillus subtilis and Proteus sp.
Key words
Juniperus thurifera - Cupressaceae - essential oil composition - cedranes - antibacterial activity - antifungal activity
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Alejandro F. Barrero
Departamento de Química Orgánica
Instituto de Biotecnología
Facultad de Ciencias
Universidad de Granada
Campus Fuentenueva s/n
18071 Granada
Spain
Phone: +34-958-243318
Fax: +34-958-243318
Email: afbarre@ugr.es