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DOI: 10.1055/s-2005-837756
Aloeresin I, an Anti-Inflammatory 5-Methylchromone from Cape Aloe
Publication History
Received: April 6, 2004
Accepted: June 27, 2004
Publication Date:
27 January 2005 (online)
![](https://www.thieme-connect.de/media/plantamedica/200501/lookinside/thumbnails/10.1055-s-2005-837756-1.jpg)
Abstract
A new diglucoside having a 5-methylchromone moiety was isolated from a commercial sample of Cape aloe, the dried exudate from Aloe ferox Miller, and named aloeresin I. Its structure was established as 1 on the basis of spectral and chemical evidence. Aloeresin I (1) (1 μmol/cm2) reduces in vivo the oedematous response (39 %) induced by Croton oil in the mouse ear with the same potency as aloesin, one of the most abundant Cape aloe constituents, and to a higher extent than aloeresin H (2). Indomethacin (0.3 μmol/cm2), the reference anti-inflammatory compound, provokes 61 % oedema inhibition.
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Giovanna Speranza
Dipartimento di Chimica Organica e Industriale
Università degli Studi di Milano
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20133 Milano
Italy
Phone: +39-2-5031-4097
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Email: giovanna. speranza@unimi.it