Planta Med 2005; 71(1): 90-92
DOI: 10.1055/s-2005-837760
Letter
© Georg Thieme Verlag KG Stuttgart · New York

Inhibitory Effects of Xanthones from Guttiferae Plants on PAF-Induced Hypotension in Mice

Hisae Oku1 , Yoshimi Ueda1 , Munekazu Iinuma2 , Kyoko Ishiguro1
  • 1School of Pharmaceutical Sciences, Mukogawa Women’s University, Nishinomiya, Japan
  • 2Gifu Pharmaceutical University, Mitahora-higashi, Gifu, Japan
Further Information

Publication History

Received: April 2, 2004

Accepted: July 24, 2004

Publication Date:
27 January 2005 (online)

Abstract

The inhibitory effects of 22 xanthones from three Guttiferae plants (Hypericum patulum, Calophyllum inophyllum and C. austroindium) on exogeneous platelet activating factor (PAF)-induced hypotension were examined using a blood pressure monitoring in vivo assay method. Guanandin (2), caloxanthone E (3), 1,3,5,6-tetrahydroxy-2-isoprenylxanthone (8), 6-deoxyjacareubin (11) and patulone (18) showed strong inhibition of PAF-induced hypotension, with inhibitory effects of more than 60 %. Their ID50 values were greater than that of ginkgolide B (BN-52 021), a natural PAF-antagonist from the Ginkgo biloba.

References

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Dr. Kyoko Ishiguro

School of Pharmaceutical Sciences

Mukogawa Women’s University

Koshien Kyuban-cho

Nishinomiya 663-8179

Japan

Phone: +81-798-45-9942

Fax: +81-798-45-9942