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Pharmacopsychiatry 2005; 38(1): 38-39
DOI: 10.1055/s-2005-837771
Letter
© Georg Thieme Verlag KG Stuttgart · New York

Reduction of Side Effects by Combining Clozapine with Amisulpride: Case Report and Short Review of Clozapine-Induced Hypersalivation

A Case ReportB. Croissant1 , D. Hermann1 , R. Olbrich1
  • 1Central Institute of Mental Health, University of Heidelberg, Mannheim, Germany
Further Information

Publication History

Received: 9.5.2004 Revised: 13.5.2004

Accepted: 8.6.2004

Publication Date:
11 February 2005 (online)

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Side effects from a high-dose clozapine treatment for a schizophrenic patient led to massive compliance problems. The dose of clozapine could be halved without recurrence of an acute psychotic symptomatology by concomitantly administering amisulpride. The side effects, especially hypersalivation, disappeared almost entirely, which in turn led to good compliance. In a short review we would like to present the pathophysiology and therapeutic options of clozapine-induced hypersalivation.

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Dr. Bernhard Croissant, MD

Department of Addictive Behavior and Addiction Medicine

Central Institute of Mental Health

University of Heidelberg

J 5

68159 Mannheim

Phone: +49 621 1703 3502

Fax: +49 621 1703 1205

Email: croissant@zi-mannheim.de