Neurodegenerative Erkrankungen des zentral-motorischen Systems in der MRT

Zusammenfassung

Neurodegenerative Erkrankungen des zentral-motorischen Systems führen oft nur zu geringen (aber funktionell bedeutsamen) Veränderungen an unterschiedlichen Teilen des Hirnparenchyms. Die MRT ist die sensitivste Methode zur Darstellung solcher Veränderungen. In diesem Beitrag werden verschiedene neurodegenerative Erkrankungen mit ihren wichtigsten klinischen Merkmalen und MRT-Befunden vorgestellt. Differenzialdiagnostisch nützliche Kriterien werden angegeben.

Abstract

Neurodegenerative diseases of the central motor system often lead to discrete but functionally important parenchymal abnormalities in various parts of the brain. MRI is the most sensitive imaging method to detect these abnormalities. Various neurodegenerative diseases are presented with their clinical symptoms and MRI findings. Criteria for differential diagnosis are provided as well.

Neurodegeneration - Motor system - MR imaging - Parkinson disease - Atypical

Literatur

• 1 Goyal M, Versnick E, Tuite P, Cyr J S, Kucharczyk W, Montanera W, Willinsky R, Mikulis D. Hypertrophic olivary degeneration: metaanalysis of the temporal evolution of MR findings.  AJNR Am J Neuroradiol. 2000;  21 1073-1077
• 2 Hanihara T, Amano N, Takahashi T, Itoh Y, Yagishita S. Hypertrophy of the inferior olivary nucleus in patients with progressive supranuclear palsy.  Eur Neurol. 1998;  39 97-102
• 3 Jack C R, Lexa F J, Trojanowski L Q, Braffman B H, Atlas S W. Normal aging, dementia and neurodegenerative disease. In: Atlas SW (Hrsg). Magnetic resonance imaging of the brain and spine. Philadelphia; Lippincott Williams & Wilkins 2002: 1178-1240
• 4 Lin J J, Lin G Y, Shih C, Shen W C. Presentation of striatal hyperintensity on T1-weighted MRI in patients with hemiballism-hemichorea caused by non-ketotic hyperglycemia: report of seven new cases and a review of literature.  J Neurol. 2001;  248 750-755
• 5 Oh S H, Lee K Y, Im J H, Lee M S. Chorea associated with non-ketotic hyperglycemia and hyperintensity basal ganglia lesion on T1-weighted brain MRI study: a meta-analysis of 53 cases including four present cases.  J Neurol Sci. 2002;  200 57-62
• 6 De Michele G, di Maio L, Filla A. et al . Childhood onset of Friedreich ataxia: a clinical and genetic study of 36 cases.  Neuropediatrics. 1996;  27 3-7
• 7 Landwehrmeyer B, Lücking C H. Degenerative Erkrankungen mit Leitsymptom Ataxie. In: Hufschmidt A, Lücking CH (Hrsg) Neurologie compact. Stuttgart; Thieme 2003: 202-206
• 8 Valk J, Barkhof F, Scheltens P. Magnetic resonance in dementia. Berlin; Springer 2002: 95-124
• 9 Adachi M, Hosoya T, Haku T, Yamaguchi K, Kawanami T. Evaluation of the substantia nigra in patients with Parkinsonian syndrome accomplished using multishot diffusion-weighted MR imaging.  AJNR Am J Neuroradiol. 1999;  20 1500-1506
• 10 Hutchinson M, Raff U, Lebedev S. MRI correlates of pathology in parkinsonism: segmented inversion recovery ratio imaging (SIRRIM).  NeuroImage. 2003;  20 1899-1902
• 11 Hutchinson M, Raff U. Structural changes of the substantia nigra in Parkinson’s disease as revealed by MR imaging.  AJNR Am J Neuroradiol. 2000;  21 697-701
• 12 Kraft E, Schwarz J, Trenkwalder C, Vogl T, Pfluger T, Oertel W H. The combination of hypointense and hyperintense signal changes on T2-weighted magnetic resonance imaging sequences: a specific marker of multiple system atrophy?.  Arch Neurol. 1999;  56 225-228
• 13 Schocke M F, Seppi K, Esterhammer R, Kremser C, Jaschke W, Poewe W, Wenning G K. Diffusion-weighted MRI differentiates the Parkinson variant of multiple system atrophy from PD.  Neurology. 2002;  58 575-580
• 14 Schocke M F, Seppi K, Esterhammer R, Kremser C, Mair K J, Czermak B V, Jaschke W, Poewe W, Wenning G K. Trace of diffusion tensor differentiates the Parkinson variant of multiple system atrophy and Parkinson’s disease.  Neuroimage. 2004;  21 1443-1451
• 15 Davie C A, Wenning G K, Barker G J, Tofts P S, Kendall B E, Quinn N, McDonald W I, Marsden C D, Miller D H. Differentiation of multiple system atrophy from idiopathic Parkinson’s disease using proton magnetic resonance spectroscopy.  Ann Neurol. 1995;  37 204-210
• 16 Federico F, Simone I L, Lucivero V, Iliceto G, de Mari M, Giannini P, Mezzapesa D M, Tarantino A, Lamberti P. Proton magnetic resonance spectroscopy in Parkinson’s disease and atypical parkinsonian disorders.  Mov Disord. 1997;  12 903-909
• 17 Perani D, Bressi S, Testa D, Grassi F, Cortelli P, Gentrini S, Savoiardo M, Caraceni T, Fazio F. Clinical/metabolic correlations in multiple system atrophy. A fludeoxyglucose F 18 positron emission tomographic study.  Arch Neurol. 1995;  52 179-185
• 18 Schulz J B, Klockgether T, Petersen D, Jauch M, Muller-Schauenburg W, Spieker S, Voigt K, Dichgans J. Multiple system atrophy: natural history, MRI morphology, and dopamine receptor imaging with 123IBZM-SPECT.  J Neurol Neurosurg Psychiatry. 1994;  57 1047-1056
• 19 Kitagaki H, Hirono N, Ishii K, Mori E. Corticobasal degeneration: evaluation of cortical atrophy by means of hemispheric surface display generated with MR images.  Radiology. 2000;  216 31-38
• 20 Warmuth-Metz M, Naumann M, Csoti I, Solymosi L. Measurement of the midbrain diameter on routine magnetic resonance imaging: a simple and accurate method of differentiating between Parkinson disease and progressive supranuclear palsy.  Arch Neurol. 2001;  58 1076-1079