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Planta Med 2005; 71(6): 566-568
DOI: 10.1055/s-2005-864161
Letter
© Georg Thieme Verlag KG Stuttgart · New York

Isolation of a New Saponin and Cytotoxic Effect of Saponins from the Root of Platycodon grandiflorum on Human Tumor Cell Lines

Young Sup Kim1 , Jeoung Seob Kim1 , Sang-Un Choi1 , Jung Sook Kim1 , Hyun Sun Lee2 , Seong Hwan Roh3 , Young Chul Jeong4 , Young-Kyoon Kim5 , Shi Yong Ryu1
  • 1Korea Research Institute of Chemical Technology, Taejeon, Korea
  • 2Korea Research Institute of Bioscience & Biotechnology, Taejeon, Korea
  • 3JangSaeng Doraji Research Institute of Biotechnology, JangSaeng Doraji Co. Ltd., Jinju, Korea
  • 4Division of Food Science, Jinju International University, Jinju, Korea
  • 5College of Forest Science, Kookmin University, Seoul, Korea
Further Information

Publication History

Received: August 13, 2004

Accepted: March 12, 2005

Publication Date:
21 June 2005 (online)

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Abstract

A novel triterpenoid saponin, deapioplatycoside E (1) was isolated from the root extract of Platycodon grandiflorum, together with the seven known saponins 2 - 8, i. e., platycoside E (2), deapioplatycodin D3 (3), platycodin D3 (4), polygalacin D2 (5), platycodin D2 (6), deapioplatycodin D (7) and platycodin D (8). The structure of the new saponin 1 was determined on the basis of spectral analysis and chemical evidence. The crude saponin fraction (ED50: ca. 10 - 15 μg/mL) and compounds 6 - 8 (ED50: ca. 4 - 18 μg/mL) exhibited significant inhibition on the proliferation of five kinds of cultured human tumor cell lines, i. e., A549 (non-small cell lung), SK-OV-3 (ovary), SK-MEL-2 (melanoma), XF498 (central nerve system) and HCT-15 (colon), in vitro.

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Dr. Shi Yong Ryu

Korea Research Institute of Chemical Technology

Yusung

P.O. Box 107

Taejeon 305-343

Korea

Phone: +82-42-860-7163

Fax: +82-42-860-7160

Email: syryu@krict.re.kr