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DOI: 10.1055/s-2005-864831
Synthesis of Racemic Tertiary Cyanohydrins
Publication History
Publication Date:
23 March 2005 (online)
![](https://www.thieme-connect.de/media/synlett/200506/lookinside/thumbnails/10.1055-s-2005-864831-1.jpg)
Abstract
The addition of TMS-CN to ketones is catalyzed by homo- and heterogeneous catalysts, which are rationally designed by the line of hydrogen bond activation, dual activation, and the general concept of green chemistry. Especially noteworthy is that those approaches could be readily transferred to enantioselective version of the art. This account describes the development of the catalyst and comparison of the catalytic capacity depending on the nature of the catalyst and structural modifications with mechanism elucidation in appropriate position.
1 Introduction
2 Through Homogeneous Catalysis
2.1 With Lewis Acids
2.2 With Organocatalysts
2.3 With Dual Activation Catalysts
2.3.1 With Bifunctional Catalysts
2.3.2 With Double-Activation Catalysts
3 Through Heterogeneous Catalysis
3.1 Prior Art
3.2 With Inorganic and Organic Salts
4 Summary and Perspectives
Key words
alcohols - catalysis - ketones - nitriles - nucleophilic additions
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