Convenient Synthesis of α,α-Difluorinated Carbonyl Compounds from Alkynes through a Fluoro-deboronation Process

Abstract

Catalytic diboration of alkynes towards alkenyl diboronates provides suitable intermediates that can be converted into α-fluorinated and α,α-difluorinated carbonyl compounds via electrophilic fluorination with Selectfluor.

alkynes - alkenyl diboronates - electrophilic fluorination - Selectfluor - α,α-difluoroketones

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