Synthesis of Precursors for Medium-Ring Aromatic Lactones

Estelle Métay; Eric Léonel; Christine Sulpice-Gaillet; Jean-Yves Nédélec

doi:10.1055/s-2005-865364

PAPER

Synthesis of Precursors for Medium-Ring Aromatic Lactones

Estelle Métay^a, Eric Léonel*^a, Christine Sulpice-Gaillet^b, Jean-Yves Nédélec^a
^a Laboratoire d’Electrochimie, Catalyse et Synthèse Organique, UMR 7582, Institut des Sciences Chimiques Seine-Amont, IFR 1780, CNRS - Université Paris XII, 2, Rue Henri Dunant, B.P. 28, 94320 Thiais, France
Fax: +33(1)49781148; e-Mail: leonel@glvt-cnrs.fr;
^b Laboratoire de Recherche sur les Polymères, UMR 7581, Institut des Sciences Chimiques Seine-Amont, IFR 1780, CNRS - Université Paris XII, 2, Rue Henri Dunant, B.P. 28, 94320 Thiais, France

Abstract

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Abstract

Hydroxyacids have been prepared via the nickel-catalysed electrochemical arylation of ethyl acrylate from an ortho-substituted aryl bromide. Protection and deprotection steps have been selected in terms of suitability and efficiency. The lactonisation was performed according to an already reported method. Two-dimensional NMR analysis has been used to ascertain the structure of the lactones formed.

Key words

electrochemical arylation - nickel catalysis - medium ring lactones

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References

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