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DOI: 10.1055/s-2005-868500
Synthesis of Stable Carbohydrate Mimetics as Potential Glycotherapeutics
Publication History
Publication Date:
29 April 2005 (online)
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Abstract
The synthesis of a variety of stable carbohydrate mimetics using a RCM approach is discussed. An esterification-RCM approach has been utilized for the preparation of a variety of alkyl, aryl β-C-glycosides as well as a number of β-C-saccharides.
1 Introduction
2 Synthesis of β-C-Glycoconjugates
3 Synthesis of β-C-Glycoglycerolipids
4 Synthesis of a β-C-Ceramide Analog
5 Synthesis of (1→6)-β-C-Disaccharides
6 Synthesis of Differentially Linked β-C-Disaccharides
7 Synthesis of β-C-Trisaccharides
8 Conclusion
Key words
carbohydrate mimetics - ring-closing metathesis - β-C-glycosides
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References
Present address: Eisai Research Institute, 4 Corporate Drive, Andover, MA, 01810, USA; maarten_postema@eri.eisai.com.
2Present address: Skaggs Institute for Chemical Biology, BCC-405 Chemistry, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA.