Use of Ultrasound in the Synthesis of 2-(Alkylamino)benzoic Acids in Water

Rolando F. Pellón; Ana Estévez-Braun; Maite L. Docampo; Ana Martín; Angel G. Ravelo

doi:10.1055/s-2005-869834

LETTER

Use of Ultrasound in the Synthesis of 2-(Alkylamino)benzoic Acids in Water

Rolando F. Pellón*^a, Ana Estévez-Braun^b, Maite L. Docampo^a, Ana Martín^a, Angel G. Ravelo^b
^a Center of Pharmaceutical Chemistry, P.O. Box 16042 Havana, Cuba
^b Instituto Universitario de Bio-Orgánica Antonio González, Universidad de la Laguna, Avda. Astrofisico F. Sanchez 2, 38206 La Laguna, Tenerife, España
Fax: +53(7)2736471; e-Mail: rolando.pellon@infomed.sld.cu;

Abstract

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Abstract

The synthesis of substituted 2-(alkylamino)benzoic acids using the Ullmann condensation with water as the solvent and utilizing ultrasound irradiation was achieved with high yields in a short reaction time.

Key words

Ullmann condensation - copper - catalysis - ultrasound - 2-(alkylamino)benzoic acids

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References

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