A New Synthetic Approach for the Synthesis of N2-Modified Guanosines

Tatjana Hofmann; Karin Zweig; Joachim W. Engels

doi:10.1055/s-2005-869905

PAPER

A New Synthetic Approach for the Synthesis of N²-Modified Guanosines

Tatjana Hofmann, Karin Zweig, Joachim W. Engels*
Institute for Organic Chemistry and Chemical Biology, Johann Wolfgang Goethe-University, Marie-Curie-Str. 11, 60439 Frankfurt am Main, Germany
Fax: +49(69)79829148; e-Mail: joachim.engels@chemie.uni-frankfurt.de;

Abstract

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Abstract

A new universal route for generating N²-modified guanosines is developed and the synthesis of two examples is shown.

Key words

alkylations - alkyl halides - DNA - nucleosides - synthesis

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References

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