Abstract
The versatile synthesis of natural product derived macrocyclic scaffolds suitable for solid- and for solution-phase chemistry is shown. The scaffolds are modified by solid-phase chemistry to yield macrocycles with two points of diversity.
Key words
combinatorial chemistry - natural products - solid-phase synthesis
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9 (7S ,11R, 12R ,13S )-11-Amino-4,12,13-trihydroxy-12-dimethoxy-7-methyl-8,9,11,12,13,14,15,16-octahydro-7H ,10H -6-oxa-benzocyclotetradecen-5-one was obtained from 4 using p -TsOH·H2 O as acid catalyst. The crystallographic data (excluding structure factors) for the structure of this compound have been deposited with the Cambridge Crystallographic Data Centre as supplementary publication number CCDC 262678. Copies of the data can be obtained free of charge on application to CCDC 12 Union Road Cambridge CB2 1 EZ UK [fax: +44 (1223)336033 or email: deposit@ccdc.cam.ac.uk]
10 PS-Merrifield resin (crosslinked with 1% 14-divinyl-benzene) diameter: 200 µm loading: 1.9 mmol/g.
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