A Facile Synthesis of Rubrolide E [1]

Abstract

A simple and efficient synthesis of rubrolide E (1e) has been demonstrated via Meerwein coupling reaction of para-anisyldiazonium chloride with N-phenylmaleimide (2), regioselective reduction of para-anisylmaleic anhydride (4), Knoevenagel condensation of butyrolactone 5 with para-anisaldehyde and de­methylation pathway.

Key words

N-phenylmaleimide - Meerwein coupling - regioselective reduction - Knoevenagel condensation - rubrolide E - total synthesis

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NCL Communication No. 6680.

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NCL Communication No. 6680.