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Synthesis 2005(12): 2029-2038
DOI: 10.1055/s-2005-870003
DOI: 10.1055/s-2005-870003
PAPER
© Georg Thieme Verlag Stuttgart · New York
Sequential Three-Component and Heck Reactions for the Synthesis of Phenanthridones
Further Information
Publication History
Received
31 January 2005
Publication Date:
14 July 2005 (online)


Abstract
A condensation-cycloaddition-cross-coupling reaction sequence has been applied to the synthesis of phenanthridone derivatives. This novel two-step procedure is based on a three-component reaction to give 2-halobenzamide-substituted cyclohexenes, which undergo palladium-catalyzed intramolecular Heck cyclizations.
Key words
domino reactions - Heck reactions - isomerizations - heterocycles - palladium