Malignant Myoepithelioma of the Rhinopharynx: Case Report

ABSTRACT

Malignant myoepitheliomas are rare tumors of salivary glands. Most occur in the parotid gland; few other sites of origin are described. Malignant myoepithelioma of the rhinopharynx has only been reported twice. Because the lesion is so rare, there are no specific indications for its treatment. We present a third case of malignant myoepithelioma in the rhinopharynx and discuss its diagnostic and therapeutic aspects.

KEYWORDS

Malignant myoepithelioma - rhinopharynx - surgical treatment

REFERENCES

• 1 Barnes L, Appel B N, Perez H, El-Attar A M. Myoepitheliomas of the head and neck: case report and review.  J Surg Oncol. 1985;  28 21-28
• 2 Sciubba J J, Brannon R B. Myoepithelioma of salivary glands: report of 23 cases.  Cancer. 1982;  49 562-572
• 3 Sheldon W H. So-called mixed tumours of the salivary glands.  Arch Pathol. 1943;  35 1-20
• 4 Stromeyer F W, Haggitt R C, Nelson J F, Hardman J M. Myoepithelioma of minor salivary gland origin.  Arch Pathol. 1975;  99 242-245
• 5 Klumpp T R, Mohr R M, Silverman C L, Tang C K, Elfenbein I B, Dardick I. Malignant myoepithelioma of the parotid gland: case report and review of the literature.  J Laryngol Otol. 1995;  109 995-998
• 6 Chaudhry A P, Satchidanand S, Peer R, Cutler L S. Myoepithelial cell adenoma of the parotid gland: a light and ultrastructural study.  Cancer. 1982;  49 288-293
• 7 Kahn L B, Schoub L. Myoepithelioma of the palate. Histochemical and ultrastructural observations.  Arch Pathol. 1973;  95 209-212
• 8 Seifert G, Sobin L H. The World Health Organization histological classification of salivary gland tumors. A commentary on the second edition.  Cancer. 1992;  70 379-385
• 9 Young J, Barker M, Robertson T et al.. A case of myoepithelial carcinoma displaying biallelic inactivation of the tumour suppressor gene APC in a patient with familial adenomatous polyposis.  J Clin Pathol. 2002;  55 230-232
• 10 Dean A, Sierra R, Alamillos F J et al.. Malignant myoepithelioma of the salivary glands: clinicopathological and immunohistochemical features.  Br J Oral Maxillofac Surg. 1999;  37 64-66
• 11 Nilles R, Lenartz T, Kaiserling E. Myoepithelial carcinoma of the nasopharynx. Case report and review of the literature.  HNO. 1993;  41 396-400
• 12 Tuncel U, Ergul G, Ozlugedik S, Unal A. Myoepithelial carcinoma in the nasopharynx: an unusual localization.  Yonsei Med J. 2004;  45 161-165
• 13 Nofal F. Spindle cell carcinoma of the nasopharynx.  J Laryngol Otol. 1983;  97 1057-1063
• 14 De Stefani A, Lerda W, Bussi M, Valente G, Cortesina G. Tumori dello spazio parafaringeo. Presentazione di un caso clinico di mioepitelioma a cellule chiare del lobo profondo della ghiandola parotide e revisione della letteratura.  Acta Otorhinolaryngol Ital. 1999;  19 276-282
• 15 Chow L T, Chow W H, Lee J C. Monomorphic epithelioid variant of malignant myoepithelioma of the parotid gland: cytologic features in fine needle aspiration (FNA).  Cytopathology. 1996;  7 279-287
• 16 Torlakovic E, Ames E D, Manivel J C, Stanley M W. Benign and malignant neoplasm of myoepithelial cells: cytologic findings.  Diagn Cytopathol. 1993;  9 655-660
• 17 el-Naggar A, Batsakis J G, Luna M A, Goepfert H, Tortoledo M E. DNA content and proliferative activity of myoepitheliomas.  J Laryngol Otol. 1989;  103 1192-1197
• 18 Ibrahim R, Bird D J, Sieler M W. Malignant myoepithelioma of the larynx with massive metastatic spread to the liver: an ultrastructural and immunocytochemical study.  Ultrastruct Pathol. 1991;  15 69-76
• 19 Savera A T, Sloman A, Huvos A G, Klimstra D S. Myoepithelial carcinoma of the salivary glands: a clinocopathologic study of 25 patients.  Am J Surg Pathol. 2000;  24 761-774
• 20 Fisch U. The infratemporal approach for nasopharyngeal tumors.  Laryngoscope. 1983;  93 36-44

This is a well-written case report of a rare disease in a rare location. The authors ably discuss the clinical and histopathologic presentation that characterizes this rare neoplasm. Because it is unlikely that a series of such tumors in this location could be developed, a description of this patient's clinical course and the review of the existing related reports represent an especially important addition to our current literature.