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Planta Med 2005; 71(7): 622-627
DOI: 10.1055/s-2005-871267
Original Paper
Pharmacology
© Georg Thieme Verlag Stuttgart · New York

In vivo Biodistribution of Ginkgolide B, a Constituent of Ginkgo biloba, Visualized by MicroPET

Makiko Suehiro1 , 4 , Norman R. Simpson2 , Mark D. Underwood3 , John Castrillon3 , Koji Nakanishi1 , Ronald van Heertum2
  • 1Department of Chemistry, Columbia University, New York, NY, USA
  • 2Department of Radiology, Columbia University, New York, NY, USA
  • 3Department of Psychiatry, Columbia University, New York, NY, USA
  • 4Citigroup Biomedical Imaging Center, Weill Medical College of Cornell University, New York, NY, USA
Further Information

Publication History

Received: August 24, 2004

Accepted: May 17, 2005

Publication Date:
18 July 2005 (online)

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Abstract

The in vivo dynamic behavior of ginkgolide B (GB), a terpene lactone constituent of the Ginkgo biloba extracts, in the living animal was visualized by positron emission tomographic (PET) imaging using a GB analogue labeled with the positron emitter 18F. The in vivo imaging studies, combined with ex vivo dissection experiments, reveal that GB exists in 2 forms in the body: the original GB with its lactone rings closed and a second form with one of the rings open. The original GB in plasma is taken up rapidly by various organs including the liver, the intestine and possibly the stomach. Consequently, in plasma, the proportion of the ionized form of GB increases dramatically with time. Thereafter the ratio between the 2 forms appears to shift slowly towards equilibrium. The results suggest that more attention needs to be focused on in vivo dynamics between the 2 forms of GB.

Key words

Ginkgolide B - positron emission tomography - in vivo biodistribution of ginkgolide B - microPET - Ginkgo biloba - Ginkgoaceae

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Makiko Suehiro, Ph. D.

Department of Radiology

Citigroup Biomedical Imaging Center

Weill Medical College of Cornell University

516 East 72nd Street

New York

NY 10021

USA

Phone: +1-212-746-5853

Email: mas2048@med.cornell.edu