Three-Component Procedure for the Synthesis of 5-Aryl-5,8-dihydroazolo[1,5-a]pyrimidine-7-carboxylic Acids

Abstract

Three-component condensation of pyruvic acid with aromatic aldehydes and some aminoazoles was developed as a procedure for the synthesis 5-aryl-5,8-dihydroazolo[1,5-a]pyrimidine-7-carboxylic acids. An influence of solvent type on the composition of the reaction products was found. The structures of the compounds obtained were proved by ¹H and ¹³C NMR spectroscopy, NOE experiments, and X-ray analysis.

Key words

heterocycles - multi-component reactions - pyruvic acid­ - aminoazoles - dihydropyrimidine derivatives

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