Endothelin-1 Levels in Patients with Paget's Disease of Bone

R. Pirzer; N. Tilly; U. Sommer; U. Liegibel; I. Grafe; P. Nawroth; C. Kasperk

doi:10.1055/s-2005-872905

Experimental and Clinical Endocrinology & Diabetes, Table of Contents

Exp Clin Endocrinol Diabetes 2005; 113(10): 598-601
DOI: 10.1055/s-2005-872905

Article

J. A. Barth Verlag in Georg Thieme Verlag KG Stuttgart · New York

Endothelin-1 Levels in Patients with Paget's Disease of Bone

R. Pirzer¹ ^, ² , N. Tilly¹ , U. Sommer¹ , U. Liegibel¹ , I. Grafe¹ , P. Nawroth¹ , C. Kasperk¹

¹Department of Medicine I, Ruprecht-Karls University Heidelberg, Heidelberg, Germany
²Department of Medicine (Cardiology, Angiology, Pneumology), Faculty of Clinical Medicine Mannheim, Ruprecht-Karls University Heidelberg, Mannheim, Germany

Abstract

A locally accelerated bone turnover is the pathophysiological basis of Paget's disease of bone (PD) and may result in severe bone deformations and pain. Affected bone sites are hypervascularized. Secreted endothelial products such as endothelin-1 (ET-1), influence bone metabolism. We investigated a possible correlation between ET-1 plasma concentrations and bone metabolism in patients with PD and whether ET-1 plasma levels are regulated by i. v. bisphosphonate treatment. Plasma ET-1 levels were determined in 22 patients with PD and found to be significantly (p = 0.006) elevated (0.75 ± 0.48 fmol/ml) compared to 19 healthy controls (0.20 ± 0.24 fmol/ml). In a group of five patients with PD, plasma ET-1 levels were determined before and after treatment with i. v. pamidronate. On the average, ET-1 levels decreased by 21 % after pamidronate infusions (p = 0.045). The results suggest that bone metabolism in pagetic bone affects endothelial cell metabolism and may also be modulated by endothelial cell products. ET-1 plasma levels may indicate PD activity.

Key words

Paget's disease - endothelin-1 - bone densitometry - bone turnover markers - bisphosphonates

Full Text

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MD PhD Christian Kasperk

Department of Medicine I
Ruprecht-Karls University Heidelberg

Im Neuenheimer Feld 410

69120 Heidelberg

Germany

Phone: + 496221568605

Fax: + 49 62 21 56 68 65

Email: christian.kasperk@med.uni-heidelberg.de