Planta Med 2005; 71(12): 1176-1178
DOI: 10.1055/s-2005-873139
Letter
© Georg Thieme Verlag KG Stuttgart · New York

Cytotoxic Activity of Some Natural and Synthetic Sesquiterpene Lactones

Maurizio Bruno1 , Sergio Rosselli1 , Antonella Maggio1 , Rosa Angela Raccuglia1 , Kenneth F. Bastow2 , Chin-Chung Wu2 , Kuo-Hsiung Lee2
  • 1Dipartimento di Chimica Organica, Università di Palermo, Palermo, Italy
  • 2Natural Products Laboratory, School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA
Further Information

Publication History

Received: April 13, 2005

Accepted: May 27, 2005

Publication Date:
10 November 2005 (online)

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Abstract

Several natural and synthetic sesquiterpene lactones with different skeletons were tested and found to be active against nine cancer cell lines. Elemane (4), heliangolane (5) and their hydroxy analogues 9 and 10, all containing an α,β-unsaturated aldehyde substituent, were the most potent compounds.