Abstract
Three new agarofuran sesquiterpenes, reissantins F - H (1 - 3), were isolated from a methanol extract of Reissantia buchananii. Their structures as well as their relative stereochemistry were established on the basis of modern mass and spectroscopic methods. Compounds 1 - 3 were assayed for cytotoxicity against HepG2 and Hep3B human liver cancer cell lines.
References
-
1
Spivey A C, Weston M, Woodhead S.
Celastraceae sesquiterpenoids: biological activity and synthesis.
Chem Soc Rev.
2002;
31
43-59
-
2
Chang F R, Hayashi K, Chen I H, Liaw C C, Bastow K F, Nakanishi Y. et al .
Antitumor agents. 228. Five new agarofurans, reissantins A - E, and cytotoxic principles from Reissantia buchananii
.
J Nat Prod.
2003;
66
1416-20
-
3 Gamlath C B, Gunatilaka A AL, Schlemper E O. Reissantioloxide: a novel epoxytriterpenoid from Reissantia indica; X-ray crystal structure. J Chem Soc Chem Commun 1988: 249-50
-
4
Gamlath C B, Gunatilaka A AL, Tezuka Y, Kikuchi T.
The structure of celastranhydride: a novel triterpene anhydride of Celastraceae.
Tetrahedron Lett.
1988;
29
109-12
-
5
Kuo Y H, Chou C J, Kuo L MY, Hu Y Y, Chen Y C, Chen C F. et al .
A sesquiterpene ester from Celastrus hindsii
.
Phytochemistry.
1996;
41
549-51
-
6
Furukawa M, Makino M, Uchiyama T, Ishimi K, Ichinohe Y, Fujimoto Y.
Sesquiterpene pyridine alkaloids from Hippocratea excelsa
.
Phytochemistry.
2002;
59
767-77
-
7
Lan Y H, Chang F R, Liaw C C, Wu C C, Chiang M Y, Wu Y C.
Digoniodiol, deoxygoniopypyrone A, and goniofupyrone A: three new styryllactones from Goniothalamus amuyon
.
Planta Med.
2005;
71
153-9
Prof. Dr. Kuo-Hsiung Lee
Natural Products Laboratory
School of Pharmacy
The University of North Carolina at Chapel Hill
Chapel Hill
NC 27599-7360
USA
Phone: +1-919-962-0066
Fax: +1-919-966-3893
Email: khlee@unc.edu