Formal Enantioselective Synthesis of (-)-Carbovir and (-)-Abacavir: An Application of the Rhodium(I)-Catalysed Tandem Hydrosilylation-Intramolecular Aldol Reaction
Marta Freiría*a, Andrew J. Whiteheada, William B. Motherwellb a Chemical Development Division, GlaxoSmithKline Medicines Research Centre, Gunnels Wood Road, Stevenage, Hertfordshire, SG1 2NY, UK Fax: +44(143)8764869; e-Mail: marta.x.freiria@gsk.com; b Christopher Ingold Laboratories, Department of Chemistry, University College London, 20 Gordon Street, London, WC1H 0AJ, UK