Regioselective Phthalimidopropyl-Modification of Carbohydrates in One Step

Abstract

A series of regioselectively 3-O-(3-phthalimidopropyl)-modified sugars was synthesized in a one-step procedure using bis-dibutyltin oxide and 3-bromopropyl phthalimide. This process offers a short access to the corresponding amino-functionalized carbohydrates, which are versatile building blocks for the synthesis of glycomimetics.

Key words

carbohydrates - glycosides - protecting groups - regioselectivity - glycomimetics

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