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DOI: 10.1055/s-2006-924003
© Georg Thieme Verlag KG Stuttgart · New York
Topical Negative Pressure Therapy in Wounds after Cardiothoracic Surgery: Successful Experience Supported by Literature
Publication History
Received January 27, 2006
Publication Date:
10 August 2006 (online)
Abstract
Background: Patients undergoing cardiothoracic surgery are at substantial risk of developing surgical site infections (SSI). SSI is not only associated with an increased morbidity but also with high mortality. Topical negative pressure therapy (TNP) is a promising method for treating surgical site defects (SSD). In recent years, we have gained a wide experience with TNP in a great variety of SSD. Methods: We completed a prospective follow-up report of all patients treated with TNP after cardiothoracic surgery at the Academic Medical Centre Amsterdam, a university hospital. A review of the current evidence for TNP in cardiothoracic surgery is presented. Results: Between August 2000 and March 2005, TNP was used in 105 patients in 113 SSD. As we gained more experience, we saw a decline in hospital stay (p < 0.0001) and duration of TNP therapy. Surgical closure was performed in 62 % of patients using simple surgical (reconstructive) techniques. Therapy-related complications were rare (n = 1). Conclusion: Based on clinical findings and supported by the research presented, the treatment modality of choice for SSD after cardiothoracic surgery is TNP.
Key words
Cardiovascular surgery - thoracic surgery - heart valve surgery - coronary bypass surgery
References
- 1 Morykwas M J, Argenta L C. Vacuum-assisted closure: a new method for wound control and treatment: animal studies and basic foundation. Ann Plast Surg. 1997; 38 553-562
- 2 Argenta L C, Morykwas M J. Vacuum-assisted closure: a new method for wound control and treatment: clinical experience. Ann Plast Surg. 1997; 38 563-576
- 3 Lambert K V, Hayes P, McCarthy M. Vacuum assisted closure: a review of development and current applications. Eur J Vasc Endovasc Surg. 2005; 29 219-226
- 4 Webb L X, Schmidt U. Wundbehandlung mit der Vakuumtherapie. Unfallchirurg. 2001; 104 918-926
- 5 Evans D, Land L. Topical negative pressure therapy for treating chronic wounds: a systemic review. Br J Plast Surg. 2001; 54 238-242
- 6 Nashef S AM, Roques F, Michel P, Gauducheau E, Lemeshow S, Salamon R. European system for cardiac operative risk evaluation (EuroSCORE). Eur J Cardiothorac Surg. 1999; 16 9-13
- 7 Wackenfors A, Gustafsson R, Sjögren J, Algotsson J, Ingemansson R, Malmsjö M. Blood flow responses in the peristernal thoracic wall during vacuum-assisted closure therapy. Ann Thorac Surg. 2005; 79 1724-1731
- 8 Dersch T, Morykwas M J, Clark M, Argenta L C. Effects on negative and positive pressure on skin oxygen tension and perfusion. The 4th Annual Meeting of Wound Healing Society in San Francisco, CA, USA. 1994
- 9 De Lange M Y, Nicolai J PA. The influence of subatmospheric pressure on tissue oxygenation and temperature. Presented at the 2nd World Union of Wound Healing Societies Meeting in Paris, France. July.8 - 13.2004
- 10 Chen S Z, Li J, Li X Y, Xu L S. Effects of vacuum-assisted closure on wound microcirculation: an experimental study. Asian J Surg. 2005; 28 211-217
-
11 Niezgoda J A, Cabigas B, Mewissen M.
A randomized controlled study comparing vacuum assisted closure to standard dressing changes in the development of angiogenesis. Proceedings of 2005 Symposium on Advanced Wound Care in San Diego, CA, USA. April.21 - 25.2005: S81 - 12 Zoech G. V.A.C. therapy and laser induced fluorescence of indocianine-green (IC-VIEW). Presented at the 2nd World Union of Wound Healing Societies Meeting in Paris, France. July.8 - 13.2004
- 13 Tang S Y, Li C L, Luo X Y, Yang Y, Li D M. Effect of vacuum-assisted closure on proliferative activity of cells during human chronic wound healing. Zhongghuo Linchuang Kangfu. 2005; 9 146-147
- 14 Ilizarov G A. The tension stress effect on the genesis and growth of tissues. Part 1. The influence of stability and fixation and soft tissue preservation. Clin Orthop. 1989; 238 249-281
- 15 Saxena V, Hwang C W, Huang S, Eischbaum Q, Ingber D, Orgill D P. Vacuum-assisted closure: microdeformations of wound and cell proliferation. Plast Reconstr Surg. 2004; 114 1086-1096
- 16 Liu P H, Lew D H, Chan R. et al . Micro-mechanical force stimulation of angiogenesis. Journal of Burn Care and Rehabilitation. 2004; 25 S52
- 17 Shi B, Chen S Z, Zhang P, Li J Q. Effects of vacuum assisted closure (VAC) on the expressions of MMP‐1, 2, 13 in human granulation wounds. Zhongua Zheng Wai Ke Ka Zhi. 2003; 19 279-281
- 18 Tang S Y, Chen S Z, Hu Z H, Song M, Cao D Y, Lu X X. Influence of vacuum-assisted closure technique on expression of BcL‐2 and NGF/NGFmRNA during wound healing. Zhongua Zheng Wai Ke Ka Zhi. 2004; 20 139-142
- 19 Kremers L, Kearns M, Daniel L, Nicolai J, Morykwas M. Involvement of p 38 mitogen activated protein kinases (map kinases) in increased wound healing during subatmospheric pressure (SAP) treatment. Presented at the European Tissue Repair Society, Focus Group Meeting, Topical Negative Pressure (TNP) Therapy, London. December.4 - 6.2003
- 20 Kremers L, Kearns M, Hammon D, Scott C A, Daniel L, Morykwas M J. Involvement of mitogen activated protein kinases (map kinases) in increased wound healing during sub-atmospheric pressure (SAP) treatment. Wound Repair and Regeneration. 2003; 11 A34
- 21 Kremers L, Wanner M, Argenta J A, Webb K, Argenta L C, Morykwas M J. Effects of sub-atmospheric pressure on PG12 and TBX-BETA2 and control visceral blood flow post burn. Wound Repair and Regeneration. 2003; 11 A34
- 22 Van Wijk M P, Kremers L, de Lange M Y, Leuvenink H GD, Nicolai J PA. Elastase activity and inhibition in vacuum assisted treated wounds. Presented at the European Tissue Repair Society, Focus Group Meeting, Topical Negative Pressure (TNP) Therapy, London. December.4 - 6.2003
- 23 Schultz G. Identifying and correcting molecular abnormalities in chronic wounds. Presented at the 2nd World Union of Wound Healing Societies Meeting in Paris, France. July.8 - 13.2004
- 24 Teot L, Trial C, Moles J P, Kilpadi D. Evolution of angiogenetic growth factors in wounds submitted to negative pressure therapy. Presented at the 2nd World Union of Wound Healing Societies Meeting in Paris, France. July.8 - 13.2004
- 25 Kopp J, Hoff C, Rosenberg B. et al . Application of VAC therapy upregulates growth factor levels in neuropathic diabetic foot ulcers. Wound Repair and Regeneration. 2003; 11 A34
- 26 Swan M C, Banwell P E, Jones S, Chave H, Tiernan E. Reverse tissue expansion and the management of the open abdomen. Presented at the European Tissue Repair Society, Focus Group Meeting, Topical Negative Pressure (TNP) Therapy, London. December.4 - 6.2003
- 27 Segers P, de Jong A P, Kloek J J, de Mol B A. Poststernotomy mediastinitis: comparison of two treatment modalities. Interact Cardiovasc Thorac Surg. 2005; 4 555-560
- 28 Sjögren J, Gustafsson R, Nilsson J, Malmsjö M, Ingemansson R. Clinical outcome after poststernotomy mediastinitis: vacuum-assisted closure versus conventional treatment. Ann Thorac Surg. 2005; 79 2049-2055
- 29 Fuchs U, Zitterman A, Stuettgen B, Groening A, Minami K, Koerfer R. Clinical outcome of patients with deep sternal wound infection managed by vacuum-assisted closure compared to conventional therapy with open packing: a retrospective analysis. Ann Thorac Surg. 2005; 79 526-531
- 30 Doss M, Martens S, Wood J P, Wolff J D, Baier C, Moritz A. Vacuum-assisted suction drainage versus conventional treatment in the management of poststernotomy osteomyelitis. Eur J Cardiothor Surg. 2002; 22 934-938
- 31 Luckraz H, Murphy F, Bryant S, Charman S C, Ritchie A J. Vacuum-assisted closure as a treatment modality for infections after cardiac surgery. J Thor Cardiovasc Surg. 2003; 125 301-305
- 32 Kutschka I, Frauendorfer P, Harringer W. Vacuum assisted closure therapy improves early postoperative lung function in patients with large sternal wounds. Zentralbl Chir. 2004; 129 S33-S34
- 33 Gwan-Nulla D, Casal R S. Toxic shock syndrome associated with the use of the vacuum-assisted closure device. Ann Plast Surg. 2001; 47 552-554
- 34 Chester D L, Waters R. Adverse alteration of wound flora with topical negative pressure therapy: a case report. Br J Plast Surg. 2002; 55 510-511
- 35 White R A, Miki R A, Kazmier P, Anglen J O. Vacuum-assisted closure complicated by erosion and hemorrhage of the anterior tibial artery. J Orthop Trauma. 2005; 19 56-59
- 36 Conquest A M, Garofalo J H, Maziarz D M. et al . Hemodynamic effect of the vacuum-assisted closure device on open mediastinal wounds. J Surg Research. 2003; 115 209-213
- 37 Moues C M, van den Bemd G J, Meerding W J, Hovius S E. An economic evaluation of the use of TNP on full-thickness wounds. J Wound Care. 2005; 14 224-227
- 38 Neubauer G, Ujlaky R. The cost-effectiveness of topical negative pressure versus other wound-healing therapies. J Wound Care. 2003; 12 392-393
- 39 Philbeck Jr T E, Whittington K T, Millsap M H, Briones R B, Wight D G, Schroeder W J. The clinical and cost effectiveness of externally applied negative pressure wound therapy in the treatment of wounds in home healthcare medicare patients. Ostomy Wound Manag. 1999; 45 41-50
MD P. Segers
Department of Cardiothoracic Surgery
Academic Medical Centre
University of Amsterdam
Meibergdreef 9
1105 AZ Amsterdam
The Netherlands
Phone: + 31205664323
Fax: + 31 2 05 66 22 89
Email: p.segers@amc.uva.nl