Relationship Between Serum Concentrations of Interleukin-6 and   Tumor Necrosis Factor Alpha in Female Turkish Subjects with Normal and Impaired   Glucose Tolerance

D. Konukoglu; H. Hatemi; H. Bayer; N. Bağrıaçık

doi:10.1055/s-2006-924974

Hormone and Metabolic Research, Table of Contents

Horm Metab Res 2006; 38(1): 34-37
DOI: 10.1055/s-2006-924974

Original Clinical

Relationship Between Serum Concentrations of Interleukin-6 and Tumor Necrosis Factor Alpha in Female Turkish Subjects with Normal and Impaired Glucose Tolerance

D. Konukoglu¹ , H. Hatemi² , H. Bayer³ , N. Bağrıaçık³

¹Istanbul University, Cerrahpasa Medical Faculty, Department of Biochemistry, Istanbul, Turkey
²Istanbul University, Cerrahpasa Medical Faculty, Department of Internal Medicine, Division of Endocrinology, Istanbul, Turkey
³Turkish Diabetes Association, Istanbul, Turkey

Abstract

Serum interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNFα) concentrations were measured in subjects during two-hour glucose loading in order to investigate the effects of glucose on serum IL-6 and TNFα concentrations. Twenty-six female subjects (mean age 60 ± 10 years) had normal glucose tolerance (NGT ) and nineteen female subjects (mean age: 63 ± 9 years) had impaired glucose tolerance (IGT ) according to WHO criteria. Serum IL-6 and TNFα concentrations were measured by chemiluminescent immunometric assay. Subjects with IGT have higher fasting serum TNFα levels than subjects with NGT (p < 0.01). Serum IL-6 and TNFα concentrations were elevated during glucose loading (for each comparision, p < 0.01). The increase in serum TNFα concentrations in IGT was greater than in NGT (p < 0.01). Serum IL-6 and TNFα concentration significantly correlated with insulin and glucose in IGT group (for each comparision, p < 0.01). The correlation between serum glucose and cytokines concentrations was significant in IGT (for each comparision, p < 0.01). There was also a positive correlation between serum IL-6 and TNFα in NGT and IGT (for each comparision, p < 0.01). In conclusion, hyperglycemia is associated with increased circulating cytokine concentrations and fasting TNFα concentrations seem to be more associated with IGT than IL-6.

Key words

Interleukin-6 - tumor necrosis factor-alpha - hyperglycemia - impaired glucose tolerance - cytokines

Full Text

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Dildar Konukoglu

Cerrahpasa Medical Faculty · Department of Biochemistry · Istanbul University

Fatih Sitesi B-4 Blok · Daire 5 · Silivrikapı · Fatih · Istanbul · Turkey

Email: dkonuk@istanbul.edu.tr