Synthesis of Functionalized Furans Based on a ‘[3+2] Cyclization/Bromination­/Elimination’ Strategy

Abstract

The bromination of 2-alkylidenetetrahydrofurans - readily available via one-pot [3+2] cyclizations - afforded 2-alkylidene-3-bromotetrahydrofurans. Elimination of hydrogen bromide and subsequent aromatization of these compounds provided a convenient approach to functionalized furans.

Keywords

bromination - elimination - furans - O-heterocycles - tetrahydrofurans

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