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Synthesis 2006(5): 765-767
DOI: 10.1055/s-2006-926327
DOI: 10.1055/s-2006-926327
SHORTPAPER
© Georg Thieme Verlag Stuttgart · New York
Multi-Component Reaction of Amines, Alkyl Propiolates, and Ninhydrin: An Efficient Protocol for the Synthesis of Tetrahydro-dihydroxy-oxoindeno[1,2-b]pyrrole Derivatives
Further Information
Received
4 July 2005
Publication Date:
07 February 2006 (online)
Publication History
Publication Date:
07 February 2006 (online)
Abstract
A new protocol for the synthesis of a series of tetrahydro-dihydroxy-oxoindeno[1,2-b]pyrrole from simple primary amines, alkyl propiolates, and ninhydrin was developed. The key step in the synthesis is an efficient three-component reaction of an amine with an alkyl propiolate to give a 3-amino acrylate derivative, which then reacts with ninhydrin.
Key words
tetrahydro-dihydroxy-oxoindeno[1,2-b]pyrrole derivatives - multicomponent reaction - cyclization
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