(Bromodimethyl)sulfonium Bromide Catalyzed One-Pot Synthesis of α-Aminonitriles [1]

Abstract

A novel, simple and efficient one-pot synthesis of α-aminonitriles has been achieved by a three-component condensation of carbonyl compounds, amines and trimethylsilyl cyanide in the presence of (bromodimethyl)sulfonium bromide as a catalyst at room temperature. The products were obtained in high yields and in short reaction times.

Keywords

α-aminonitriles - carbonyl compounds - amines - trimethylsilyl cyanide - (bromodimethyl)sulfonium bromide

1

Part 67 in the series ‘Studies on novel synthetic methodologies’; IICT Communication no. 051101.

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1

Part 67 in the series ‘Studies on novel synthetic methodologies’; IICT Communication no. 051101.