Abstract
A novel synthesis of the 2,6′-O-linkage of methyl α-d-glucoside and methyl α-d-mannoside was developed based on an acetalization-reduction approach. Utilizing this approach, the 3,6′-O-linkage of methyl α-d-glucosides was also obtained. It is noteworthy that the reductive etherification of secondary alcohols and the C6-aldehyde of carbohydrates proceeded efficiently.
Key words
carbohydrate - acetals - ethers - reductions - regioselectivity
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