Novel Approaches to Fused Phospha-Pyrimidines

Dmitriy M. Volochnyuk; Svetlana A. Kovaleva; Alexandr N. Chernega; Nataliya G. Chubaruk; Alexandr N. Kostyuk; Alexandr M. Pinchuk; Andrey A. Tolmachev; Reinhard Schmutzler

doi:10.1055/s-2006-926460

PAPER

Novel Approaches to Fused Phospha-Pyrimidines

Dmitriy M. Volochnyuk*^a, Svetlana A. Kovaleva^a, Alexandr N. Chernega^a, Nataliya G. Chubaruk^a, Alexandr N. Kostyuk^a, Alexandr M. Pinchuk^a, Andrey A. Tolmachev^b, Reinhard Schmutzler^c
^a Institute of Organic Chemistry, National Academy of Sciences of Ukraine, Murmanska 5, Kiev-94, 02094, Ukraine
Fax: +380(44)5373253; e-Mail: D.Volochnyuk@enamine.net;
^b Research and Development Center for Chemistry and Biology, National Taras Shevchenko University, 62 Volodymyrska St., Kiev-33, 01033, Ukraine
^c Institute of Inorganic and Analytical Chemistry, Technical University, Hagenring 30, 38106 Braunschweig, Germany

Abstract

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Abstract

Simple methods for the preparation of phosphorus-containing fused pyrimidine analogues such as fused 1,5,2-diazaphosphinines from amidine derivatives of π-excessive heterocycles are described. The scope and limitations of the methodology are detailed.

Key words

phospha-pyrimidines - amidines - phosphorus(III) halides - phosphorylation - heterocyclization

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Crystallographic data (excluding structure factors) for the structures reported in this paper have been deposited with the Cambridge Crystallographic Data Center as supplementary publication no. CCDC-256274 (27) and CCDC-256890 (38) and can be obtained free of charge on application to CCDC, 12 Union Road, Cambridge CB2 1EZ, UK [Fax: +44(1223)336033; E-mail: deposit@ccdc.cam.ac.uk]