Planta Med 2006; 72(7): 604-610
DOI: 10.1055/s-2006-931556
Original Paper
Pharmacology
© Georg Thieme Verlag KG Stuttgart · New York

Antiproliferative Activity of Pteleopsis suberosa Leaf Extract and its Flavonoid Components in Human Prostate Carcinoma Cells

Marinella De Leo1 , Alessandra Braca1 , Rokia Sanogo2 , Venera Cardile3 , Nunziatina DeTommasi4 , Alessandra Russo5
  • 1Dipartimento di Chimica Bioorganica e Biofarmacia, Università di Pisa, Pisa, Italy
  • 2Departement Medicine Traditionelle (DMT), INRSP, Bamako, Mali
  • 3Dipartimento di Scienze Fisiologiche, Università di Catania, Catania, Italy
  • 4Dipartimento di Scienze Farmaceutiche, Università di Salerno, Fisciano, Salerno, Italy
  • 5Dipartimento di Chimica Biologica, Chimica Medica e Biologia Molecolare, Università di Catania, Catania Italy
Further Information

Publication History

Received: July 27, 2005

Accepted: January 15, 2006

Publication Date:
24 April 2006 (online)

Abstract

In this work we describe the chemical composition of Pteleopsis suberosa (Combretaceae) leaf extract and its biological activity against androgen-insensitive human prostate cancer cells (DU-145). The methanol extract of the plant leaves exhibited activity against tumor cell growth. Fractionation of this active extract led to the isolation and identification of sixteen flavonoids, including gallocatechin and flavonols having kaempferol, quercetin, and myricetin as aglycones. Among the myricetin derivatives, myricetin 3-O-(3′′-acetyl)-α-L-arabinopyranoside (1) and myricetin 3-O-(4′′-acetyl)-α-L-arabinopyranoside (2) are now reported for the first time. Six compounds, myricetin 3-O-α-L-rhamnopyranoside (4), myricetin 3-O-β-D-galactopyranoside (7), myricetin 3-O-(6′′-galloyl)-β-D-galactopyranoside (9), myricetin 3-O-β-D-xylopyranoside (10), myricetin 3-O-α-L-arabinofuranoside (12), and gallocatechin (14), exhibited significant activity, reducing cell vitality and inducing apoptosis via the caspase-dependent pathway in DU-145 cells that can be, in part, correlated to modulation of redox-sensitive mechanisms.

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Prof. Nunziatina DeTommasi

Dipartimento di Scienze Farmaceutiche

Università di Salerno

Via Ponte Don Melillo

84084 Fisciano (SA)

Italy

Fax: +39-089-962-647

Email: detommasi@unisa.it