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Semin Thromb Hemost 2006; 32(1): 005-010
DOI: 10.1055/s-2006-933335
Copyright © 2006 by Thieme Medical Publishers, Inc., 333 Seventh Avenue, New York, NY 10001, USA.

Tissue Factor in Hemostasis and Thrombosis

Rachel Tilley1 , Nigel Mackman1 , 2
  • 1Department of Immunology, The Scripps Research Institute, La Jolla, California
  • 2Department Cell Biology, The Scripps Research Institute, La Jolla, California
Further Information

Publication History

Publication Date:
15 February 2006 (online)

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ABSTRACT

Tissue factor (TF) plays an essential role in hemostasis. The tissue-specific pattern of TF expression is consistent with additional hemostatic protection in vital organs. An aberrant expression of TF within the vasculature occurs in a variety of diseases, including atherosclerosis, cancer, and sepsis. TF expression in these diseases is associated with thrombotic events. Future therapeutic strategies may prove beneficial in the treatment of thrombosis. However, these strategies should be designed to avoid compromising hemostasis.

KEYWORDS

Tissue factor - hemostasis - thrombosis - procoagulant - anticoagulant

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Nigel MackmanPh.D. 

Department Cell Biology, The Scripps Research Institute

10550 North Torrey Pines Road, La Jolla, CA 92037

Email: nmackman@scripps.edu