Zusammenfassung
Hintergrund: Odontogene, also von den zahnbildenden Geweben ausgehende Tumoren stellen eine heterogene Gruppe von Neoplasien inner-halb der Mundhöhle dar, deren Verhalten von echten Fehlbildungen bis zu hoch malignen Tumoren reicht.
Patient: Wir beschreiben den Fall eines vierjährigen Mädchens, welches durch den fehlenden Durchbruch eines Milchzahns und einen korrespondierenden maxillären Tumor auffiel. Die Raumforderung wurde nach chirurgischer Entfernung als ameloblastisches Fibroodontom klassifiziert. Diese außerordentlich seltene Geschwulst ist der Gruppe der odontogenen Tumoren zuzu-rechnen.
Diskussion: In Anlehnung an den Fallbericht wird die Vielfalt odontogener Tumoren hinsicht-lich ihrer Tumorbiologie, ihrer Klinik und ihrer Therapiemöglichkeiten im Kindesalter vor-gestellt.
Schlussfolgerung: Kinder- und Jugendmediziner sollten bei entsprechenden Beschwerden oder klinischen Symptomen auch die Möglichkeit einer solchen Neoplasie in Betracht ziehen.
Abstract
Background: Odontogenic tumors are a heterogenic group of neoplasias of the oral cavity, whose biological behaviour reaches from true hamartomas to highly malignant tumors.
Patient: We describe the case of a 4 year old caucasian girl presenting with eruption disturbance of a primary tooth and corresponding maxillary tumor. After surgical removal of the mass, histological examination classified the tumor as ameloblastic fibroodontoma. This very rare neoplasm is of odontogenic origin.
Discussion: Following our case report, the variety of odontogenic tumors regarding tumor biology, clinical symptoms and therapeutic options in childhood are discussed.
Conclusion: In case of complaints or clinical symptoms paediatricians should take the possibility of such neoplasias into consideration.
Schlüsselwörter
Kiefertumoren - odontogene Tumoren - ameloblastisches Fibroodontom - WHO-Klassifikation
Key words
Jaw tumors - odontogenic tumors - ameloblastic fibroodontoma - WHO classification
Literatur
-
1
Al-Khateeb T, Al-Hadi Hamasha A, Almasri NM.
Oral and maxillofacial tumours in north Jordanian children and adolescents: a retrospective analysis over 10 years.
Int J Oral Maxillofac Surg.
2003;
32
78-83
-
2
Arotiba JT, Ogunbiyi JO, Obicchina AE.
Odontogenic tumors: a 15-year review from Ibadan, Nigeria.
Brit J Oral Maxillofac Surg.
1997;
35
363-367
-
3 Bhaskar SN. Synopsis der Mundkrankheiten. Medica, Stuttgart 1971
-
4
Daley TD, Wysocki GP, Pringle GA.
Relative incidence of odontogenic tumors in oral and jaw cysts in a Canadian population.
Oral Surg Oral Med Oral Pathol.
1994;
77
276-280
-
5
Ehrenfeld M, Donath K, Riediger D, Mast G, Gärtner HV.
Ameloblastome im Wachstumsalter - differenzialdiagnostische und therapeutische Aspekte.
Dtsch Zahnärztl Z.
1991;
46
77-79
-
6 Freyschmidt J, Ostertag H, Jundt G. Knochentumoren. Klinik, Radiologie, Pathologie. 2. Aufl. Springer, Berlin, Heidelberg, New York 1998
-
7
Grätz KW, Makek M, Sailer HF.
Das ameloblastische Fibro-Odontom.
Dtsch Zahnärztl Z.
1991;
46
71-73
-
8
Gundlach KKH.
Odontogene Tumoren.
Mund Kiefer Gesichtschir.
2000;
4
((Suppl 1))
187-195
-
9
Günhan Ö, Erseven G, Ruacan S, Celasun B, Aydintug Y, Ergun E, Demiriz M.
Odontogenic tumors: a series of 409 cases.
Austr Dental J.
1990;
35
518-522
-
10
Herzog U, Putzke HP, Bienengräber V, Radke C.
Das ameloblastische Fibroodontom - ein odontogener Mischtumor mit Übergang in ein odontogenes Sarkom.
Dtsch Z Mund Kiefer Gesichtschir.
1991;
15
90-93
-
11
Kumar N, Jain S.
Aspiration cytology of ameloblastic fibroma: a diagnostic challenge.
Diagn Cytopathol.
2003;
29
101-104
-
12
Ladeinde AL, Ajayi OF, Ogunlewe MO, Adeyemo WL, Arotiba GT, Bamgbose BO, Akinwande JA.
Odontogenic tumors: a review of 319 cases in a Nigerian teaching hospital.
Oral Surg Oral Med Oral Pathol Oral Radiol Endod.
2005;
99
191-195
-
13
Lentrodt J, Gundlach KKH.
Zur chirurgischen Therapie der gutartigen odontogenen Tumoren.
Dtsch Z Mund Kiefer Gesichtschir.
1978;
2
3-14
-
14
Lu Y, Xuan M, Takata T, Wang C, He Z, Zhou Z, Mock D, Nikai H.
Odontogenic tumors. A demographic study of 759 cases in a Chinese population.
Oral Surg Oral Med Oral Pathol Oral Radiol Endod.
1998;
86
707-714
-
15
Maaita JK.
Oral tumours in children: a review.
J Clin Ped Dent.
2000;
24
133-135
-
16
Martin-Duverneuil N, Roisin-Chausson MH, Behin A, Favre-Dauvergne E, Chiras J.
Combined benign odontogenic tumors: CT and MR findings and histomorphologic evaluation.
Am J Neuroradiol.
2001;
22
867-872
-
17
Minami M, Kaneda T, Yamamoto H, Ozawa K, Itay Y, Ozawa M, Yoshikawa K, Sasaki Y.
Ameloblastoma in the maxillomandibular region: MR imaging.
Radiology.
1992;
184
389-393
-
18
Mosqueda-Taylor A, Ledesma-Montes C, Caballero-Sandoval S, Portilla- Robertson J, Ruiz-Godoy Rivera LM, Meneses-Garcia A.
Odontogenic tumors in Mexiko. A collaborative study of 349 cases.
Oral Surg Oral Med Oral Pathol Oral Radiol Endod.
1997;
84
672-675
-
19
Mothes P, Kreusch T, Harms D, Donath K, Schmelzle R.
Die Häufigkeit odontogener Tumoren im Wachstumsalter.
Dtsch Zahnärztl Z.
1991;
46
18-19
-
20
Philipsen HP, Reichart PA, Praetorius F.
Mixed odontogenic tumors and odontomas. Considerations on interrelationship. Review of the literature and presentation of 134 new cases of odontomas.
Eur J Cancer B Oral Oncol.
1997;
33
86-99
-
21
Pindborg JJ, Clausen F.
Classification of odontogenic tumors. A suggestion.
Acta Odontol Scand.
1958;
16
293-301
-
22
Regezi JA, Kerr DA, Courtney RM.
Odontogenic tumors: an analysis of 706 cases.
J Oral Surg.
1978;
36
771-778
-
23 Regezi JA, Sciubba JJ. Oral pathology: clinical pathologic correlations. 3rd ed. W. B. Saunders, Philadelphia 1999
-
24
Reichard PA, Zobl H.
Transformation of ameloblastic fibroma into fibrosarcoma. Report of a case.
Int J Oral Surg.
1978;
5
503-507
-
25
Reichart PA, Philipsen HP, Sonner S.
Ameloblastoma: biologic profile of 3677 cases.
Eur J Cancer B Oral Oncol.
1995;
31B
86-99
-
26 Reichart PA, Philipsen HP. Odontogenic tumors and allied lesions. Quintessence, London 2004
-
27
Sato M, Tanaka M, Sato T, Amagasa T.
Oral and maxillofacial tumors in children: a review.
Brit J Oral Maxillofac Surg.
1997;
63
92-95
-
28
Schmidtseder R, Hausamen JE.
Multiple odontogenic tumors and other anomalies.
Oral Surg Oral Med Oral Pathol Oral Radiol Endod.
1975;
39
249-258
-
29 Sciubba JJ, Fantasia JE, Kahn LB. Tumors and cysts of the jaws. 3rd ed. Armed Forces Institute of Pathology, Washington 2001
-
30
Slootweg PJ.
An analysis of the interrelationship of the mixed odontogenic tumors - ameloblastic fibroma, ameloblastic fibroodontoma, and the odontomas.
Oral Surg Oral Med Oral Pathol Oral Radiol Endod.
1981;
51
266-276
-
31
Takeda Y.
So-called “immature dentinoma”: a case presentation and histological comparison with ameloblastic fibrodentinoma.
J Oral Path Med.
1994;
23
92-96
-
32
Tamme T, Soots M, Kulla A, Karu K, Hanstein SM, Sokk A, Joeste E, Leibur E.
Odontogenic tumours, a collaborative retrospective study of cases covering more than 25 years from Estonia.
J Craniomaxillofac Surg.
2004;
32
161-165
-
33
Tanaka N, Murata A, Yamaguchi A, Kohama G.
Clinical features of oral and maxillofacial tumors in children.
Oral Surg Oral Med Oral Pathol Oral Radiol Endod.
1999;
88
11-15
-
34
Thoma KH, Goldman HM.
Odontogenic tumors. A classification based on observations of the epithelial, mesenchymal and mixed varieties.
Am J Pathol.
1946;
22
433-471
-
35
Trodahl JN.
Ameloblastic fibroma. A survey of cases from the Armed Forces Institute of Pathology.
Oral Surg Oral Med Oral Pathol.
1972;
33
547-558
-
36 WHO .International histological classification of tumors. No. 5 Pindborg JJ, Kramer IRH, Torloni H (eds) Histological typing of odontogenic tumours, jaw cysts, and allied lesions. WHO, Genf 1971
-
37 WHO .International histological classification of tumors. Kramer IRH, Pindborg JJ, ShearM (eds). Histological typing of odontogenic tumours. 2nd edn. Springer, Berlin, Heidelberg, New York 1992
-
38
Wu PC, Chan KW.
A survey of tumours of the jawbones in Hong Kong Chinese: 1963-1982.
Brit J Oral Maxillofac Surg.
1985;
23
92-102
-
39
Yamamoto K, Yoneda K, Yamamoto T, Ueta E, Osaki T.
An immunohistochemical study of odontogenic mixed tumors.
Eur J Cancer B Oral Oncol.
1995;
31B
122-128
Korrespondenzadresse
PD Dr. Dr. D. Hermes
Sektion Kiefer- und Gesichts-chirurgie
Universitäts-klinikum Schleswig-Holstein/Campus Lübeck
Ratzeburger Allee 160
23538 Lübeck
Phone: +49/451/500 22 69
Email: hermesddd@aol.com
