Microwave-Assisted Raney Nickel Reduction of Bispidinone Thioketals to N,N′-Dialkylbispidines

Lauri Toom; Helena Grennberg; Adolf Gogoll

doi:10.1055/s-2006-942394

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Microwave-Assisted Raney Nickel Reduction of Bispidinone Thioketals to N,N′-Dialkylbispidines

Lauri Toom, Helena Grennberg, Adolf Gogoll*
Department of Biochemistry and Organic Chemistry, Uppsala University, Box 576, 75123 Uppsala, Sweden
Fax: +46(18)4713818; e-Mail: Adolf.Gogoll@kemi.uu.se;

Abstract

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Abstract

A series of N,N′-dialkyl-3,7-diazabicyclo[3.3.1]nonanes was prepared by microwave-assisted reduction of a common dithiolane precursor with Raney nickel, using the corresponding alkanol as solvent. The method avoids the use of hydrazine.

Key words

alkylations - bicyclic compounds - deoxygenation - desulfurizations - microwave-assisted synthesis

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