Facile Synthesis of Steroidal [16,17-c]Tetrahydropyridazine Derivatives by One-Pot Stille Coupling and Hetero-Diels-Alder Reactions

Abstract

The synthesis of new steroidal [16,17-c]tetrahydropyridazine derivatives as mixtures of 16α- and 16β-isomers has been accomplished by consecutive Stille coupling and hetero-Diels-Alder reactions. The products were obtained in a one-pot reaction without the isolation of the diene intermediates.

Key words

cycloadditions - Stille reaction - steroids - palladium - annulations­

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