Abstract
The stability of andrographolide in powdered Andrographis Herb - the aerial part of Andrographis paniculata (Burm. f.) Nees (Acanthaceae) - was determined using a heat-accelerated experiment to reveal a second-order kinetics of degradation. The fast decomposition was observed regardless of the method of analysis. The rate constant of the decomposition of andrographolide at 25 °C (k
25
°C), predicted from the Arrhenius plot, was 6.58 × 10-6 d-1.
References
-
1 Thai Herbal P harmacopoeia, 2nd e dn. Bangkok; Prachachon Co. Ltd 1998: p 24-31
-
2
A Rahman N NN, Furuta T, Kojima S, Takane K, Mohd M A.
Antimalarial activity of extracts of Malaysian medicinal plants.
J Ethnopharmacol.
1999;
64
249-54
-
3
Collins R A, Ng T B, Fong W P, Wan C C, Yeung H W.
A comparison of human immunodeficiency virus type I inhibition of partially purified aqueous extracts of Chinese medicinal herbs.
Life Sci.
1997;
60
PL345-51
-
4
Kumar R A, Sridevi K, Kumar N V, Nanduri S, Rajagopal S.
Anticancer and immunostimulatory compounds from Andrographis paniculata
.
J Ethnopharmacol.
2004;
92
291-5
-
5
Nanduri S, Nyavanandi V K, Thunuguntla S SR, Kasu S, Pallerla M K, Ram P S. et al .
Synthesis and structure-activity relationships of andrographolide analogues as novel cytotoxic agents.
Bioorg Med Chem Lett.
2004;
14
4711-7
-
6
Patwardhan B, Warude D, Pushpangadan P, Bhatt N.
Ayurveda and traditional Chinese medicine: a comparative overview.
Evid Based Complement Alternat Med.
2005;
2
465-73
-
7 Capasso F, Gaginella T S, Grandolini G, Izzo A A. Phytotherapy: a quick reference to herbal medicine. Berlin; Springer 2003: p 382
-
8
Cava M P, Chan W R, Haynes L J, Johnson L F, Weinstein B.
The structure of andrographolide.
Tetrahedron.
1962;
18
397-403
-
9 Dechatiwongse Na Ayudhya T, Techadamrongsin Y, Jirawattanapong W. Chemical specification of Thai herbal drugs. Vol. 1 Bangkok; Department of Medical Sciences, Ministry of Public Health 1993: p 24-41
-
10
Lomlim L, Jirayupong N, Plubrukarn A.
Heat-accelerated degradation of solid-state andrographolide.
Chem Pharm Bull.
2003;
51
24-6
-
11
Wongkittipong R, Prat L, Damronglerd S, Gourdon C.
Solid-liquid extraction of andrographolide from plants - experimental study, kinetics reaction and model.
Sep Purif Technol.
2004;
40
147-54
-
12
Pholphana N, Rangkadilok N, Thongnest S, Ruchirawat S, Ruchirawat M, Satayavivad J.
Determination and variation of three active diterpenoids in Andrographis paniculata (Burm.f) Nees.
Phytochem Anal.
2004;
15
365-71
-
13
Fujita T, Fujitani R, Takeda Y, Takaishi Y, Yamada T, Kido M. et al .
On the diterpenoids of Andrographis paniculata: X-ray crystallographic analysis of andrographolide and structure determination of new minor diterpenoids.
Chem Pharm Bull.
1984;
32
2117-25
Anuchit Plubrukarn
Department of Pharmacognosy and Pharmaceutical Botany
Faculty of Pharmaceutical Sciences
Prince of Songkla University
Hat-Yai
Songkhla 90112
Thailand
Phone: +66-7442-8220
Fax: +66-7442-8220
Email: anuchit.pl@psu.ac.th