Planta Med 2006; 72(13): 1244-1247
DOI: 10.1055/s-2006-947200
Letter
© Georg Thieme Verlag KG Stuttgart · New York

New Dihydrodibenzoxepins from Bulbophyllum kwangtungense

Bin Wu1 , Shan He1 , Yuan-jiang Pan1
  • 1Department of Chemistry, Zhejiang University, Hangzhou, P.R. China
Further Information

Publication History

Received: February 12, 2006

Accepted: June 17, 2006

Publication Date:
18 September 2006 (online)

Abstract

Three new dihydrodibenzoxepins 7,8-dihydro-5-hydroxy-12,13-methylenedioxy-11-methoxyldibenz[b,f]oxepin (1), 7,8-dihydro-4-hydroxy-12,13-methylenedioxy-11-methoxyldibenz[b,f]oxepin (2), and 7,8-dihydro-3-hydroxy-12,13-methylenedioxy-11-methoxyldibenz[b,f]oxepin (3), were isolated from Bulbophyllum kwangtungense Schlecht, along with three known compounds, cumulatin (4), densiflorol A (5) and plicatol B (6). Their structures were established by a combination of 1D and 2D NMR spectroscopic techniques. All new compounds (1 - 3) and the known compound densiflorol A (5) exhibited anti-tumor activities against HeLa and K562 human tumor cell lines.

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Prof. Yuan-Jiang Pan

Department of Chemistry

Zhejiang University

Hangzhou 310027

People’s Republic of China

Phone: +86-571-879-51264

Fax: +86-571-879-51264

Email: panyuanjiang@zju.edu.cn