Planta Med 2006; 72(14): 1328-1330
DOI: 10.1055/s-2006-947264
Letter
© Georg Thieme Verlag KG Stuttgart · New York

Hinokiresinol Inhibits IgE-induced Mouse Passive Cutaneous Anaphylaxis Reaction

Eun-Ah Bae1 , Eun-Kyung Park1 , Hye-Joung Yang2 , Nam-In Baek2 , Dong-Hyun Kim1
  • 1College of Pharmacy, Kyung Hee University, Seoul, Korea
  • 2Graduate School of Biotechnology and PMRC, Kyung Hee University, Kyunggi-Do, Korea
Further Information

Publication History

Received: April 21, 2006

Accepted: August 14, 2006

Publication Date:
18 October 2006 (online)

Abstract

The antiallergic effect of hinokiresinol isolated from the whole plant of Trapa pseudoincisa S. at. Z. was measured in vitro and in vivo. Hinokiresinol not only potently inhibited β-hexosaminidase release from RBL-2H3 cells induced by IgE, with an IC50 value of 98 μM, but also inhibited the proinflammatory cytokines IL-6, IL-4 and TNF-α in RBL-2H3 cells stimulated by IgE. Orally and intraperitoneally administered hinokiresinol potently inhibited the passive anaphylaxis reaction in mice induced by IgE.

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Prof. Dr. Dong-Hyun Kim

College of Pharmacy

Kyung-Hee University

1 Hoegi

Dongdaemun-ku

Seoul 130-701

Korea

Phone: +82-2-961-0374

Fax: +82-2-957-5030

Email: dhkim@khu.ac.kr