Synthesis 2006(20): 3405-3408  
DOI: 10.1055/s-2006-950213
PAPER
© Georg Thieme Verlag Stuttgart · New York

An Unexpected Formation of 2-Aryl-3-benzyl-1,3-thiazolidin-4-ones

Wilson Cunico*, Liliane R. Capri, Claudia R. B. Gomes, Rosangela H. Sizilio, Solange M. S. V. Wardell
FioCruz - Fundação Oswaldo Cruz, Instituto de Tecnologia em Fármacos, FarManguinhos R. Sizenando Nabuco, 100 Manguinhos, Rio de Janeiro 21041-250, RJ, Brazil
e-Mail: wjcunico@far.fiocruz.br;
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Publication History

Received 23 May 2006
Publication Date:
21 August 2006 (online)

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Abstract

The reactions of l-valine, arenealdehydes, mercaptoacetic acid and DIPEA produce 2-aryl-3-benzyl-1,3-thiazolidin-4-ones with moderate yields (48-65%). Characterization of the 1,3-thiazolidin-4-ones was achieved by NMR and confirmed by X-ray crystallography.