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Horm Metab Res 2006; 38(9): 592-597
DOI: 10.1055/s-2006-951307
Original Clinical

© Georg Thieme Verlag KG Stuttgart · New York

Insertion/Deletion Polymorphism on ACE Gene is Associated with Endothelial Dysfunction in Young Patients with Hypertension

A. Penesova 1 , E. Cizmarova 2 , R. Kvetnansky 1 , J. Koska 1 , B. Sedlakova 3 , O. Krizanova 3
  • 1Institute of Experimental Endocrinology Slovak Academy of Sciences, Bratislava, Slovakia
  • 2Cardiology Clinic, Karlova Ves, Bratislava, Slovakia
  • 3Institute of Molecular Physiology and Genetics Slovak Academy of Sciences, Bratislava, Slovakia
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Publication History

Received 31 January 2006

Accepted after revision 29 May 2006

Publication Date:
18 September 2006 (online)

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Abstract

Endothelial dysfunction, insulin resistance (IR) and genetic predispositions are important risk factors of hypertension. Aim of our study was to test the hypothesis, whether insertion/deletion (I/D) polymorphism on the angiotensin converting enzyme (ACE) gene and M235T polymorphism on angiotesinogen gene (AGT) correlates with parameters of insulin sensitivity and plasminogen activator inhibitor (PAI-1) levels in newly diagnosed hypertensive patients as compared with normotensive controls. Blood pressure (BP), fasting plasma glucose, insulin, epinephrine, norepinephrine and PAI-1 concentrations were determined in 30 male patients with hypertension grade 1 (HT) and in 31 matched healthy subjects (NT). Insulin resistance was estimated using IR HOMA formula. Patients with HT had increased levels of PAI-1, norepinephrine, fasting plasma insulin levels, IR HOMA (p<0.001) compared to controls. Subjects (HT and NT) with DD and ID genotype had a significantly higher systolic BP (p<0.05) and PAI-1 compared to those with II genotype. Homozygous subjects 235T had a higher systolic BP and higher levels of epinephrine and norepinephrine than heterozygous or homozygous M235 (p<0.05). In conclusion, no association was found between M235T polymorphism and insulin resistance or PAI-1 levels, but results indicate relationship between I/D polymorphism of the ACE gene and plasma PAI-1 levels in the early stage of hypertension.

Key words

Blood pressure - insertion/deletion (I/D) polymorphism - angiotensin converting enzyme (ACE) - hypertension - PAI-1

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Correspondence

Adela PenesovaM.D. 

Institute of Experimental Endocrinology·Slovak Academy of Sciences

Vlarska 3·833 06 Bratislava·Slovakia

Phone: +421/2/54 77 49 42

Fax: +421/2/54 77 42 47

Email: Adela.Penesova@savba.sk