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Planta Med 2006; 72(14): 1341-1343
DOI: 10.1055/s-2006-951689
Letter
© Georg Thieme Verlag KG Stuttgart · New York

A Novel Isoflavonoid from Millettia puguensis

Modest C. Kapingu1 , Zakaria H. Mbwambo1 , Mainen J. Moshi1 , Joseph J. Magadula1 , Paul Cos2 , Dirk Vanden Berghe2 , Louis Maes3 , Mart Theunis2 , Sandra Apers2 , Luc Pieters2 , Arnold Vlietinck2
  • 1Institute of Traditional Medicine, Muhimbili University College of Health Sciences, Dar es Salaam, Tanzania
  • 2Department of Pharmaceutical, University of Antwerp, Antwerp, Belgium
  • 3Department of Biomedical Sciences, University of Antwerp, Antwerp, Belgium
Further Information

Publication History

Received: May 30, 2006

Accepted: August 14, 2006

Publication Date:
20 October 2006 (online)

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Abstract

From the roots of Millettia puguensis (Leguminosae), a novel isoflavonoid (5), 2′-methoxy-4′,5′-methylenedioxy-7,8-[2-(1-methylethenyl)furo]isoflavone, and four known compounds, i. e., lupeol (1), (-)-maackiain (2), 6,7-dimethoxy-3′,4′-methylenedioxyisoflavone (3) and 7,2′-dimethoxy-4′,5′-methylenedioxyisoflavone (4) were isolated and identified by 1H-, 13C-NMR and mass spectroscopy. All compounds were evaluated for their antiprotozoal and cytotoxic activities, but only a moderate antileishmanial activity was observed for compound 3 (IC50 = 32 μM against Leishmania infantum), and a moderate cytotoxicity for compound 2 (IC50 = 43 μM on MRC-5 cells).

References

  • 1 Dagne E, Bekele A. C-Prenylated isoflavones from Millettia ferruginea .  Phytochemistry. 1990;  29 2679-82
    CrossrefPubMedSearch in Google Scholar
  • 2 Mbwambo Z H, Apers S, Moshi M J, Kapingu M C, Van Miert S, Claeys M. et al . Anthranoid compounds with antiprotozoal activity from Vismia orientalis .  Planta Med. 2004;  70 706-10
    Thieme ConnectPubMedSearch in Google Scholar
  • 3 Mbwambo Z H, Kapingu M C, Moshi M J, Machumi F, Apers S, Cos P. et al . Antiparasitic activity of some xanthones and biflavonoids from the root bark of Garcinia livingstonei .  J Nat Prod. 2006;  69 369-72
    CrossrefPubMedSearch in Google Scholar
  • 4 Bedir E, Calis I, Aquino R, Piacente S, Pizza C. Trojanoside H: a cycloartane-type glycoside from the aerial parts of Astragalus trojanus .  Pytochemistry. 1999;  51 1017-20
    PubMedSearch in Google Scholar
  • 5 Dictionary of Natural Products on CD-ROM, Version 14 : 2. London, Boca Raton; Chapman & Hall/CRC 2006
    Search in Google Scholar
  • 6 Marques D D, Machado M IL, De Carvalho M G, Da C Meleira L A, Braz-Filho R. Isoflavonoids and triterpenoids isolated from Pterodon polygalaeflorus .  J Braz Chem Soc. 1998;  9 295-301
    PubMedSearch in Google Scholar
  • 7 Veitch N C, Sutton P SE, Kite G A, Ireland H E. Six new isoflavones and a 5-deoxyflavonol glycoside from the leaves of Ateleia herbert-smithii .  J Nat Prod. 2003;  66 210-6
    CrossrefPubMedSearch in Google Scholar
  • 8 Dahiya J S, Strange R N, Bilyard K G, Cooksey C J, Garratt P J. Two isoprenylated isoflavone phytoalexins from Cajanus cajan .  Phytochemistry. 1984;  23 871-3
    CrossrefPubMedSearch in Google Scholar
  • 9 Salem M M, Werbovetz K A. Isoflavonoids and other compounds from Psorothamnus arborescens with antiprotozoal activities.  J Nat Prod. 2006;  69 43-9
    CrossrefPubMedSearch in Google Scholar

Modest C. Kapingu

Institute of Traditional Medicine

Muhimbili University College of Health Sciences

P.O. Box 65001

Dar es Salaam

Tanzania

Email: mkapingu@muchs.ac.tz