Planta Med 2006; 72(14): 1347-1349
DOI: 10.1055/s-2006-951735
Letter
© Georg Thieme Verlag KG Stuttgart · New York

Potent Antitumor Activity of 3,4-seco-8βH-Ferna-4(23),9(11)-dien-3-oic Acid (EC-2) and 3,4-seco-Oleana-4(23),18-dien-3-oic Acid (EC-4), Evaluated by an in vitro Human Cancer Cell Line Panel

Reiko Tanaka1 , Shun-ichi Wada1 , Takeshi Yamada1 , Takao Yamori2
  • 1Department of Medicinal Chemistry, Osaka University of Pharmaceutical Sciences, Takatsuki, Osaka, Japan
  • 2Division of Molecular Pharmacology, Cancer Chemotherapy Center, Japanese Foundation for Cancer Research, Koto-ku, Tokyo, Japan
Further Information

Publication History

Received: May 8, 2006

Accepted: August 25, 2006

Publication Date:
18 October 2006 (online)

Abstract

3,4-seco-8βH-Ferna-4(23),9(11)-dien-3-oic acid (EC-2) (1) and 3,4-seco-oleana-4(23),18-dien-3-oic acid (EC-4) (2) isolated from the whole herb of Euphorbia chamaesyce L. were evaluated for their anti-tumor activities using a panel including 39 human cancer cell lines (HCC) coupled with a drug sensitivity database. Compounds 1 and 2 showed strong cytotoxicity against the HCC panel, even though alcohols 1a and 2a and methyl esters 1b and 2b were inactive.

References

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Dr. Reiko Tanaka

Department of Medicinal Chemistry

Osaka University of Pharmaceutical Sciences

4-20-1 Nasahara

Takatsuki

Osaka 569-1094

Japan

Phone: +81-72-690-1084

Fax: +81-72-690-1084

Email: tanakar@gly.oups.ac.jp