Abstract
Psychological tests based on visual information processing have shown to be promising
in predicting neurodevelopmental outcome in infants at risk. In the present study
we prospectively investigated the early development in a group of 20 high-risk preterm
infants by means of i) the Fagan Test of Infant Intelligence at 7, 9, and 12 months
postterm and ii) a detailed battery for the early assessment of visual functions at
6 and 10 months postterm. The results were then correlated to the Griffiths development
scales at two years. At around 7 months no correlation was found in our infants between
the Fagan test and neurodevelopmental outcome, possibly as a consequence of the influence
of abnormal oculomotor behaviour. At around 9 months most of the visual abnormalities
were no more present and the Fagan test was significantly correlated with the outcome.
At 12 months postterm a decline of the predictive value of the FTII was observed.
In conclusion, nine months postterm age appears to be the best age for the early assessment
of neurodevelopmental outcome in high-risk preterm infants, as the maturation of the
attentional and visual systems allows a more reliable evaluation.
Key words
Preterm - information processing - Fagan test - vision - neurodevelopment
References
- 1
Alexander G R, Kogan M, Bader D, Carlo W, Allen M, Mor J.
US birth weight/gestational age-specific neonatal mortality: 1995 - 1997 rates for
whites, hispanics, and blacks.
Pediatrics.
2003;
111
e61-66
- 2
Andersson H W.
The Fagan Test of Infant Intelligence: predictive validity in a random sample.
Psychol Rep.
1996;
78
1015-1026
- 3 Atkinson J. The developing visual brain. Oxford; Oxford University Press 2000
- 4
Atkinson J, Hood B, Wattam-Bell J, Braddick O.
Changes in infants' ability to switch visual attention in the first three months of
life.
Perception.
1992;
21
643-653
- 5
Barnett A L, Guzzetta A, Mercuri E, Henderson S E, Haataja L, Cowan F. et al .
Can the Griffiths scales predict neuromotor and perceptual-motor impairment in term
infants with neonatal encephalopathy?.
Arch Dis Child.
2004;
89
637-643
- 6
Biagioni E, Bartalena L, Biver P, Pieri R, Cioni G.
Electroencephalographic dysmaturity in preterm infants: a prognostic tool in the early
postnatal period.
Neuropediatrics.
1996;
27
311-316
- 7
Biagioni E, Bartalena L, Boldrini A, Cioni G, Giancola S, Ipata A E.
Background EEG activity in preterm infants: correlation of outcome with selected maturational
features.
Electroencephalogr Clin Neurophysiol.
1994;
91
154-162
- 8
Bornstein M H, Sigman M D.
Continuity in mental development from infancy.
Child Dev.
1986;
57
251-274
- 9
Bowen J R, Gibson F L, Leslie G I, Arnold J D, Ma P J, Starte D R.
Predictive value of the Griffiths assessment in extremely low birthweight infants.
J Paediatr Child Health.
1996;
32
25-30
- 10
Cioni G, Bertuccelli B, Boldrini A, Canapicchi R, Fazzi B, Guzzetta A. et al .
Correlation between visual function, neurodevelopmental outcome, and magnetic resonance
imaging findings in infants with periventricular leucomalacia.
Arch Dis Child Fetal Neonatal Ed.
2000;
82
F134-140
- 11
Cioni G, Ferrari F, Einspieler C, Paolicelli P B, Barbani M T, Prechtl H F.
Comparison between observation of spontaneous movements and neurologic examination
in preterm infants.
J Pediatr.
1997;
130
704-711
- 12
Cohen S E, Parmelee A H.
Prediction of five-year Stanford-Binet scores in preterm infants.
Child Dev.
1983;
54
1242-1253
- 13
de Vries L S, Eken P, Dubowitz L M.
The spectrum of leukomalacia using cranial ultrasound.
Behav Brain Res.
1992;
49
1-6
- 14
DiLalla L F, Thompson L A, Plomin R, Phillips K, Fagan I IIJF, Haith M M. et al .
Infant predictors of preschool and adult IQ: A study of infant twins and their parents.
Developmental Psychology.
1990;
26
759-769
- 15 Fagan III J F, Shepherd P A. The Fagan test of infant intelligence. Cleveland,
OH; Infantest Corporation 1991
- 16 Fagan III J F, Shepherd P A. The Fagan test of infant intelligence. Cleveland,
OH; Infantest Corporation 1986
- 17
Fagan J F.
The relationship of novelty preferences during infancy to later intelligence and later
recognition memory.
Intelligence.
1984;
8
339-346
- 18
Fagan 3rd J F.
Selective screening device for the early detection of normal or delayed cognitive
development in infants at risk for later mental retardation.
Pediatrics.
1986;
78
1021-1026
- 19 Fagan J F, Shepherd P A. The Fagan test of infant intelligence. Cleveland, OH;
Infantest Corporation 1991
- 20 Griffiths R. The abilities of young children: a comprehensive system of mental
measurement for the first eight years of life. The Test Agency 1984
- 21
Guzzetta A, Cioni G, Cowan F, Mercuri E.
Visual disorders in children with brain lesions: 1. Maturation of visual function
in infants with neonatal brain lesions: correlation with neuroimaging.
Eur J Paediatr Neurol.
2001;
5
107-114
- 22
Guzzetta A, Fazzi B, Mercuri E, Bertuccelli B, Canapicchi R, van Hof-van Duin J. et
al .
Visual function in children with hemiplegia in the first years of life.
Dev Med Child Neurol.
2001;
43
321-329
- 23
Guzzetta A, Mercuri E, Cioni G.
Visual disorders in children with brain lesions: 2. Visual impairment associated with
cerebral palsy.
Eur J Paediatr Neurol.
2001;
5
115-119
- 24
Hoyert D L, Mathews T J, Menacker F, Strobino D M, Guyer B.
Annual summary of vital statistics: 2004.
Pediatrics.
2006;
117
168-183
- 25 Illingworth R S. The normal child. Some problems of the early years and their treatment. Edinburgh;
Churchill Livingstone 1991
- 26 Kopp C B, McCall R B.
Predicting later mental performance for normal, at-risk, and handicapped infants. Baltes PB, and Brim OG Life-span development and behavior. New York; Academic Press
1982: 33-61
- 27
Largo R H, Graf S, Kundu S, Hunziker U, Molinari L.
Predicting developmental outcome at school age from infant tests of normal, at-risk
and retarded infants.
Dev Med Child Neurol.
1990;
32
30-45
- 28 McCall R B.
The development of intellectual functioning in infancy and the prediction of later
IQ. Osofsky JD Handbook of infant development. New York; Wiley 1979: 707-740
- 29
McCall R B, Carriger M S.
A meta-analysis of infant habituation and recognition memory performance as predictors
of later IQ.
Child Dev.
1993;
64
57-79
- 30
McCormick M C.
The contribution of low birth weight to infant mortality and childhood morbidity.
N Engl J Med.
1985;
312
82-90
- 31
McDonald M A, Dobson V, Sebris S L, Baitch L, Varner D, Teller D Y.
The acuity card procedure: a rapid test of infant acuity.
Invest Ophthalmol Vis Sci.
1985;
26
1158-1162
- 32
Mercuri E, Anker S, Guzzetta A, Barnett A, Haataja L, Rutherford M. et al .
Neonatal cerebral infarction and visual function at school age.
Arch Dis Child Fetal Neonatal Ed.
2003;
88
F487-491
- 33
Mercuri E, Anker S, Guzzetta A, Barnett A L, Haataja L, Rutherford M. et al .
Visual function at school age in children with neonatal encephalopathy and low Apgar
scores.
Arch Dis Child Fetal Neonatal Ed.
2004;
89
F258-262
- 34
Mercuri E, Haataja L, Guzzetta A, Anker S, Cowan F, Rutherford M. et al .
Visual function in term infants with hypoxic-ischaemic insults: correlation with neurodevelopment
at 2 years of age.
Arch Dis Child Fetal Neonatal Ed.
1999;
80
F99-104
- 35
Miller G, Dubowitz L M, Palmer P.
Follow-up of pre-term infants: is correction of the developmental quotient for prematurity
helpful?.
Early Hum Dev.
1984;
9
137-144
- 36
Mirmiran M, Barnes P D, Keller K, Constantinou J C, Fleisher B E, Hintz S R. et al
.
Neonatal brain magnetic resonance imaging before discharge is better than serial cranial
ultrasound in predicting cerebral palsy in very low birth weight preterm infants.
Pediatrics.
2004;
114
992-998
- 37
Mohn G, Van Hof-van Duin J.
Behavioural and electrophysiological measures of visual functions in children with
neurological disorders.
Behav Brain Res.
1983;
10
177-187
- 38
O'Connor M J.
A comparison of preterm and full-term infants on auditory discrimination at four months
and on Bayley Scales of Infant Development at eighteen months.
Child Dev.
1980;
51
81-88
- 39
Parmelee Jr A H, Schulte F J.
Developmental testing of pre-term and small-for-date infants.
Pediatrics.
1970;
45
21-28
- 40
Rademaker K J, Uiterwaal C S, Beek F J, van Haastert I C, Lieftink A F, Groenendaal F.
et al .
Neonatal cranial ultrasound versus MRI and neurodevelopmental outcome at school age
in children born preterm.
Arch Dis Child Fetal Neonatal Ed.
2005;
90
F489-493
- 41
Rando T, Bancale A, Baranello G, Bini M, De Belvis A G, Epifanio R. et al .
Visual function in infants with West syndrome: correlation with EEG patterns.
Epilepsia.
2004;
45
781-786
- 42
Rose S A, Feldman J F.
Infant visual attention: Stability of individual differences from 6 to 8 months.
Developmental Psychology.
1987;
23
490-498
- 43
Rose S A, Feldman J F, Wallace I F.
Individual differences in infants' information processing: Reliability, stability
and prediction.
Child Development.
1988;
59
1177-1197
- 44
Rose S A, Feldman J F, Wallace I F.
Infant Information Processing in relation to six-year cognitive outcome.
Child Development.
1992;
63
1126-1141
- 45
Rose S A, Feldman J F, Wallace I F, Cohen P.
Language: A partial link between infant attention and later intelligence.
Developmental Psychology.
1991;
27
798-805
- 46
Rose S A, Feldman J F, Wallace I F, McCarton C.
Infant visual attention: relation to birth status and developmental outcome during
the first five years.
Developmental Psychology.
1989;
25
560-576
- 47
Rose S A, Feldman J F, Wallace I F, McCarton C.
Information processing at 1 year: Relation to birth status and developmental outcome
during the first 5 years.
Developmental Psychology.
1991;
27
723-737
- 48
Siegel L S.
Correction for prematurity and its consequences for the assessment of the very low
birth weight infant.
Child Development.
1983;
54
1176-1188
- 49
Sigman M, Cohen S E, Beckwith L, Parmelee A H.
Infant attention in relation to intellectual abilities in childhood.
Developmental Psychology.
1986;
23
788-792
- 50
Slater A.
Individual differences in infancy and later IQ.
J Child Psychol Psychiatry.
1995;
36
69-112
- 51
Slater A, Cooper R, Rose D, Morrison V.
Prediction of cognitive performance from infancy to early childhood.
Human Development.
1989;
32
137-147
- 52
Smith L, Ulvund S E, Lindemann R.
Very low birth weight infants (< 1501 g) at double risk.
J Dev Behav Pediatr.
1994;
15
7-13
- 53
Sontheimer D.
Visual information processing in infancy.
Dev Med Child Neurol.
1989;
31
787-796
- 54 Spreen O, Risser A H, Edgell D. Developmental neuropsychology. New York; Oxford
University Press 1995
- 55 Sternberg R J, Grigorenko E L, Bundy D A. The predictive value of IQ. Quarterly
2001
- 56
Tasbihsazan R, Nettelbeck T, Kirby N.
Predictive validity of the Fagan Test of Infant Intelligence.
British Journal of Developmental Psychology.
2003;
21
585-597
- 57
Van den Hout B M, Eken P, Van der Linden D, Wittebol-Post D, Aleman S, Jennekens-Schinkel A.
et al .
Visual, cognitive, and neurodevelopmental outcome at 5 1/2 years in children with
perinatal haemorrhagic-ischaemic brain lesions.
Dev Med Child Neurol.
1998;
40
820-828
- 58
van Hof-van Duin J, Cioni G, Bertuccelli B, Fazzi B, Romano C, Boldrini A.
Visual outcome at 5 years of newborn infants at risk of cerebral visual impairment.
Dev Med Child Neurol.
1998;
40
302-309
- 59
van Hof-van Duin J, Heersema D J, Groenendaal F, Baerts W, Fetter W P.
Visual field and grating acuity development in low-risk preterm infants during the
first 2 1/2 years after term.
Behav Brain Res.
1992;
49
115-122
- 60
van Hof-van Duin J, Mohn G.
The development of visual acuity in normal fullterm and preterm infants.
Vision Res.
1986;
26
909-916
- 61
Volpe J J.
Intraventricular hemorrhage and brain injury in the premature infant. Neuropathology
and pathogenesis.
Clin Perinatol.
1989;
16
361-386
Prof. Giovanni Cioni
Department of Developmental Neuroscience
Stella Maris Scientific Institute
Via dei Giacinti 2
56018 Calambrone (Pisa)
Italy
Email: g.cioni@inpe.unipi.it