Abstract
The use of methylsulfonylmethane (MSM), available as an “over-the-counter” dietary
supplement, led to the occurrence of an abnormal resonance at 3.15 ppm in the in vivo brain proton MR spectrum as well as the in vitro cerebrospinal fluid NMR study of
a 4-year-old girl. The concentration of this compound amounted to 1.2 mmol/l in brain
tissue and 1.7 mmol/l in cerebrospinal fluid. Our findings illustrate that ingestion
of exogenous compounds, e.g., in medication, food or “innocent” supplements, may lead
to abnormal resonances in spectroscopy studies that might be difficult to assign.
Key words
Methylsulfonylmethane - dimethyl sulfone - proton magnetic resonance spectroscopy
- NMR
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MD, PhD M. A. A. P. Willemsen
Radboud University Nijmegen Medical Centre
Department of Pediatric Neurology (820 IKNC)
PO Box 9101
NL-6500 HB Nijmegen
The Netherlands
Email: m.willemsen@cukz.umcn.nl
