ABSTRACT
Idiopathic pulmonary fibrosis (IPF), also referred to as cryptogenic fibrosing alveolitis (CFA), is the clinical-radiological-pathological syndrome associated with the most common form of fibrosing interstitial pneumonia, usual interstitial pneumonia (UIP). Unfortunately, the diagnosis of IPF carries with it a relatively poor prognosis. The characteristic features on high-resolution computed tomography (HRCT), consisting of reticular abnormality and honeycombing with basal and peripheral predominance, are virtually diagnostic within the correct clinical context. The extent of fibrosis on HRCT is an important prognostic indicator. When ground-glass attenuation is seen in patients with IPF, it commonly progresses to fibrosis and honeycombing. Complications of IPF include accelerated progression and deterioration, lung cancer, spontaneous air leak, and secondary infection. This article discusses the key imaging features as correlated with histopathology, differential diagnosis, complications, and follow-up evaluation of idiopathic pulmonary fibrosis.
KEYWORDS
High-resolution computed tomography - idiopathic pulmonary fibrosis - usual interstitial pneumonia (UIP)
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Jonathan G GoldinMBChB Ph.D.
Department of Radiology, David Geffen School of Medicine at UCLA
10833 Le Conte Ave., B2-165 CHS, Los Angeles, CA 90095-1721
Email: jgoldin@mednet.ucla.edu
